Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR5088928

9a84d684-c634-599a-9578-ac0351df2172

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR5088904
melanoma-umap@29
0.957
2SRR5088860
melanoma-umap@29
0.953
3SRR5088905
melanoma-umap@29
0.951
4TCGA-A2-A0EN-01A-13R-A084-07
breast-umap@18
A0.942
5ERR2208937
melanoma-umap@29
0.932
6TCGA-55-7281-01A-11R-2039-07
lung-landscapes@6
cohortA10.925
7c5e09ad2-1f0b-4ea3-9565-a1664f1bb468
melanoma-umap@29
0.922
8TCGA-77-A5FZ-01A-31R-A27Q-07
lung-landscapes@6
cohortMD20.921
9TCGA-99-8028-01A-11R-2241-07
lung-landscapes@6
cohortMD20.920
10SRR5088910
melanoma-umap@29
0.919

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 27 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.500Idelalisib— uncovered
COMPLEMENT0.500Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.500Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.500Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.500Idelalisib— uncovered
ANGIOGENESIS0.400Remibrutinib— uncovered
COAGULATION0.400Binimetinib— uncovered
INTERFERON_GAMMA_RESPONSE0.400Idelalisib— uncovered
KRAS_SIGNALING_UP0.400Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.400Inavolisib— uncovered
APICAL_JUNCTION0.300Inavolisib— uncovered
APICAL_SURFACE0.300Temsirolimus— uncovered
APOPTOSIS0.300Idelalisib— uncovered
HYPOXIA0.300Idelalisib— uncovered
IL2_STAT5_SIGNALING0.300Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.300Inavolisib— uncovered
MYOGENESIS0.300Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.300Inavolisib— uncovered
KRAS_SIGNALING_DN0.200Remibrutinib— uncovered
NOTCH_SIGNALING0.200Inavolisib— uncovered