SRR1444460
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.442
- SPERMATOGENESIS+0.223
- PANCREAS_BETA_CELLS+0.202
- MYOGENESIS+0.182
- BILE_ACID_METABOLISM+0.147
- APICAL_SURFACE+0.102
- APICAL_JUNCTION+0.069
- XENOBIOTIC_METABOLISM+0.057
- ESTROGEN_RESPONSE_LATE+0.027
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.026
Top 10 suppressed
- PROTEIN_SECRETION-0.570
- MYC_TARGETS_V1-0.552
- MTORC1_SIGNALING-0.481
- UNFOLDED_PROTEIN_RESPONSE-0.472
- ANDROGEN_RESPONSE-0.423
- E2F_TARGETS-0.400
- TGF_BETA_SIGNALING-0.378
- G2M_CHECKPOINT-0.377
- INTERFERON_GAMMA_RESPONSE-0.344
- PI3K_AKT_MTOR_SIGNALING-0.341
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1311794 | GTEX | — | 0.954 |
| 2 | SRR602927 | GTEX | — | 0.945 |
| 3 | SRR1400997 | GTEX | — | 0.943 |
| 4 | SJEPD007_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.943 |
| 5 | SJEPD001530_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.941 |
| 6 | SJEPD030_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.938 |
| 7 | SRR1315269 | GTEX | — | 0.934 |
| 8 | MNG1044 | — | — | 0.930 |
| 9 | SRR1490465 | GTEX | — | 0.929 |
| 10 | SRR1797231 | — | cohortSC | 0.927 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.442 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.223 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.202 | Cobimetinib | — uncovered |
| MYOGENESIS | 0.182 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.147 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.102 | Temsirolimus | — uncovered |
| APICAL_JUNCTION | 0.069 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.057 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.027 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.026 | Inavolisib | — uncovered |