MNG1044
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.406
- PANCREAS_BETA_CELLS+0.372
- SPERMATOGENESIS+0.247
- MYOGENESIS+0.060
- BILE_ACID_METABOLISM+0.051
- ESTROGEN_RESPONSE_LATE+0.043
- COAGULATION+0.032
- APICAL_SURFACE-0.017
- ESTROGEN_RESPONSE_EARLY-0.021
- APICAL_JUNCTION-0.084
Top 10 suppressed
- MYC_TARGETS_V2-0.587
- UNFOLDED_PROTEIN_RESPONSE-0.582
- MYC_TARGETS_V1-0.571
- TGF_BETA_SIGNALING-0.569
- PROTEIN_SECRETION-0.507
- E2F_TARGETS-0.487
- G2M_CHECKPOINT-0.475
- DNA_REPAIR-0.472
- MITOTIC_SPINDLE-0.472
- TNFA_SIGNALING_VIA_NFKB-0.472
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG226 | — | — | 0.974 |
| 2 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.969 |
| 3 | SRR602927 | GTEX | — | 0.969 |
| 4 | 8ad884fa-e426-4bc0-960d-08db42d341da | — | — | 0.966 |
| 5 | MNG599 | — | — | 0.963 |
| 6 | SRR1336379 | GTEX | — | 0.963 |
| 7 | 08e3d239-3d8a-4eee-9e08-ac2bcb3f2619 | — | — | 0.962 |
| 8 | MNG1133 | — | — | 0.962 |
| 9 | SRR1490465 | GTEX | — | 0.961 |
| 10 | TCGA-CF-A8HX-01A-11R-A36F-07 | — | — | 0.960 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.406 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.372 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.247 | Inavolisib | — uncovered |
| MYOGENESIS | 0.060 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.051 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.043 | Idelalisib | — uncovered |
| COAGULATION | 0.032 | Binimetinib | — uncovered |