SRR6013514

— · cohortMD2

0778e8ab-a069-5303-bee8-24ef093ae8ff

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortMD2
subtype: cohortMD2

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	X038167c2.c7d9.47a2.9172.1cfe391c8131 lung-landscapes@6	—	cohortMD2	0.944
2	MBCProject_1819_T2A_RNA breast-umap@18	—	A	0.938
3	TCGA-77-A5FZ-01A-31R-A27Q-07 lung-landscapes@6	—	cohortMD2	0.923
4	TCGA-AN-A0FN-01A-11R-A034-07 breast-umap@18	—	A	0.917
5	f22cfa82-a346-4fed-bc81-21a29bf990ee colon-landscapes@1	—	—	0.911
6	C3N-02923 lung-landscapes@6	—	cohortMD2	0.911
7	c277dab0-361f-4aa6-96b1-522a6e556ae1 colon-landscapes@1	—	—	0.909
8	TCGA-XF-AAME-01A-12R-A42T-07 bladder-landscape@3	—	—	0.906
9	ec054d40-e5b8-496a-8c99-5e7f88f2cf37 colon-landscapes@1	—	—	0.905
10	2cec663c-00c8-48b5-967b-f2a53c0fb409 colon-landscapes@1	—	—	0.903

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 26 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
ALLOGRAFT_REJECTION	0.560	Idelalisib	— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION	0.560	Inavolisib	— uncovered
COMPLEMENT	0.490	Inavolisib	— uncovered
ANGIOGENESIS	0.470	Remibrutinib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.450	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.450	Idelalisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.450	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.410	Idelalisib	— uncovered
IL2_STAT5_SIGNALING	0.370	Idelalisib	— uncovered
COAGULATION	0.340	Binimetinib	— uncovered
KRAS_SIGNALING_UP	0.320	Inavolisib	— uncovered
MYOGENESIS	0.320	Inavolisib	— uncovered
UV_RESPONSE_DN	0.320	Inavolisib	— uncovered
HYPOXIA	0.310	Idelalisib	— uncovered
APOPTOSIS	0.280	Idelalisib	— uncovered
PANCREAS_BETA_CELLS	0.260	Cobimetinib	— uncovered
TGF_BETA_SIGNALING	0.210	Inavolisib	— uncovered
APICAL_SURFACE	0.170	Temsirolimus	— uncovered
APICAL_JUNCTION	0.150	Inavolisib	— uncovered
INTERFERON_ALPHA_RESPONSE	0.130	Inavolisib	— uncovered