X038167c2.c7d9.47a2.9172.1cfe391c8131

— · cohortMD2

b39623af-8237-5b95-b5c2-f3c80bbba2a4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortMD2
subtype: cohortMD2
age_years: 48

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR6013514 lung-landscapes@6	—	cohortMD2	0.944
2	TCGA-77-A5FZ-01A-31R-A27Q-07 lung-landscapes@6	—	cohortMD2	0.935
3	TCGA-99-8028-01A-11R-2241-07 lung-landscapes@6	—	cohortMD2	0.921
4	C3L-02164 lung-landscapes@6	—	cohortMD2	0.915
5	TCGA-XF-AAME-01A-12R-A42T-07 bladder-landscape@3	—	—	0.913
6	SRR821602 brain-umap@2	GTEX	—	0.913
7	SRR1382532 brain-umap@2	GTEX	—	0.908
8	SRR33346958 bladder-landscape@3	—	—	0.906
9	TCGA-A2-A0EP-01A-52R-A22U-07 breast-umap@18	—	A	0.905
10	TCGA-22-4596-01A-01R-1201-07 lung-landscapes@6	—	cohortA1	0.902

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
ALLOGRAFT_REJECTION	0.620	Idelalisib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.580	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.570	Idelalisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.570	Inavolisib	— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION	0.530	Inavolisib	— uncovered
COMPLEMENT	0.470	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.440	Idelalisib	— uncovered
IL2_STAT5_SIGNALING	0.370	Idelalisib	— uncovered
KRAS_SIGNALING_UP	0.370	Inavolisib	— uncovered
ANGIOGENESIS	0.340	Remibrutinib	— uncovered
COAGULATION	0.340	Binimetinib	— uncovered
HYPOXIA	0.270	Idelalisib	— uncovered
PANCREAS_BETA_CELLS	0.270	Cobimetinib	— uncovered
APOPTOSIS	0.230	Idelalisib	— uncovered
APICAL_SURFACE	0.220	Temsirolimus	— uncovered
INTERFERON_ALPHA_RESPONSE	0.220	Inavolisib	— uncovered
UV_RESPONSE_DN	0.210	Inavolisib	— uncovered
MYOGENESIS	0.150	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.140	Remibrutinib	— uncovered
TGF_BETA_SIGNALING	0.130	Inavolisib	— uncovered