Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

C3N-01489

· cohortA1

08fd56b2-99eb-5593-9ac0-601987bf48b1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA1
subtype
cohortA1
age_years
65.18822724

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1SRR818469
brain-umap@2
GTEX0.887
2c5e09ad2-1f0b-4ea3-9565-a1664f1bb468
melanoma-umap@29
0.884
3TCGA-98-A53D-01A-32R-A262-07
lung-landscapes@6
cohortMD20.883
4sclcA055A_S52.txt
lung-landscapes@6
cohortMD20.876
5SRR601787
brain-umap@2
GTEX0.875
6X25d3a106.8a9a.4285.9b02.1ba01b7a9ad2
lung-landscapes@6
cohortMD20.871
7SRR1099023
brain-umap@2
GTEX0.866
8TCGA-44-A47G-01A-21R-A24H-07
lung-landscapes@6
cohortA10.865
9SRR1444932
brain-umap@2
GTEX0.865
10ERR2598314
medullo-epn-umap@date-based
fetalfetal0.865

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 29 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.450Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.410Inavolisib— uncovered
ANGIOGENESIS0.390Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.390Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.390Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.370Inavolisib— uncovered
COAGULATION0.350Binimetinib— uncovered
COMPLEMENT0.330Inavolisib— uncovered
IL2_STAT5_SIGNALING0.330Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.270Idelalisib— uncovered
KRAS_SIGNALING_UP0.270Inavolisib— uncovered
APICAL_JUNCTION0.260Inavolisib— uncovered
APICAL_SURFACE0.260Temsirolimus— uncovered
HYPOXIA0.210Idelalisib— uncovered
MYOGENESIS0.210Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.190Inavolisib— uncovered
UV_RESPONSE_UP0.170Idelalisib— uncovered
PANCREAS_BETA_CELLS0.160Cobimetinib— uncovered
ESTROGEN_RESPONSE_LATE0.150Idelalisib— uncovered
KRAS_SIGNALING_DN0.150Remibrutinib— uncovered