ERR2598320
fetal · fetal
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- fetal
- cancer_type_detailed
- —
- subtype
- fetal
- cancer_type
- fetal
- subtype
- fetal
- sex
- fetal
- race
- fetal
- fetal_age_hindbrain
- 20
- umap1_2d
- -4.990975297
- umap2_2d
- -2.319714411
- umap1_3d
- 1.232967069
- umap2_3d
- 2.194965469
- umap3_3d
- -0.633712145
- dataset
- fetal
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.690
- INTERFERON_GAMMA_RESPONSE+0.510
- OXIDATIVE_PHOSPHORYLATION+0.350
- PANCREAS_BETA_CELLS+0.350
- COAGULATION+0.300
- COMPLEMENT+0.290
- P53_PATHWAY+0.290
- XENOBIOTIC_METABOLISM+0.290
- IL6_JAK_STAT3_SIGNALING+0.280
- ADIPOGENESIS+0.260
Top 10 suppressed
- G2M_CHECKPOINT-0.470
- E2F_TARGETS-0.440
- MYC_TARGETS_V2-0.390
- MITOTIC_SPINDLE-0.350
- MTORC1_SIGNALING-0.340
- TGF_BETA_SIGNALING-0.340
- HEDGEHOG_SIGNALING-0.280
- UNFOLDED_PROTEIN_RESPONSE-0.270
- UV_RESPONSE_DN-0.260
- MYC_TARGETS_V1-0.230
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-AC-A5XS-01A-11R-A29R-07 | — | B | 0.905 |
| 2 | da7cbc0a-95dc-4303-a5dd-75857c066f3b | — | — | 0.898 |
| 3 | TCGA-67-3773-01A-01R-0946-07 | — | cohortA1 | 0.883 |
| 4 | TCGA-34-5234-01A-01R-1635-07 | — | cohortSQ1 | 0.877 |
| 5 | ERR2598328 | fetal | fetal | 0.877 |
| 6 | SAMN03290925 | — | — | 0.862 |
| 7 | TCGA-BA-A6DB-01A-11R-A30B-07 | — | — | 0.860 |
| 8 | ERR2598280 | fetal | fetal | 0.854 |
| 9 | ERR2598268 | fetal | fetal | 0.852 |
| 10 | C3L-02560 | — | cohortA1 | 0.845 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 26 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.690 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.510 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.350 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.350 | Cobimetinib | — uncovered |
| COAGULATION | 0.300 | Binimetinib | — uncovered |
| COMPLEMENT | 0.290 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.290 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.290 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.280 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.260 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.260 | Idelalisib | — uncovered |
| MYOGENESIS | 0.250 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.250 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.230 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.200 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.190 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.170 | Idelalisib | — uncovered |
| APOPTOSIS | 0.150 | Idelalisib | — uncovered |
| PEROXISOME | 0.140 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.120 | Inavolisib | — uncovered |