C3L-02661

— · cohortA1

0b78457e-749b-5f1b-9b0e-7dc1bb8fca1c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortA1
subtype: cohortA1
age_years: 59.22518823

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR6013521 lung-landscapes@6	—	cohortA1	0.817
2	TCGA-D8-A1XB-01A-11R-A14D-07 breast-umap@18	—	A	0.812
3	MBCProject_0044_T1_RNA breast-umap@18	—	A	0.802
4	SRR8613779 breast-umap@18	—	D	0.792
5	ERR2208936 melanoma-umap@29	—	—	0.789
6	SRR10900592 melanoma-umap@29	—	—	0.772
7	7b3b5487-3788-4498-b9a2-0fd77967ad66 colon-landscapes@1	—	—	0.772
8	TCGA-56-8626-01A-11R-2403-07 lung-landscapes@6	—	cohortSQ1	0.770
9	MBCProject_0832_T1_RNA breast-umap@18	—	A	0.765
10	SRR1516096 bladder-landscape@3	—	—	0.756

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION	0.580	Inavolisib	— uncovered
ANGIOGENESIS	0.520	Remibrutinib	— uncovered
TGF_BETA_SIGNALING	0.440	Inavolisib	— uncovered
NOTCH_SIGNALING	0.380	Inavolisib	— uncovered
APICAL_JUNCTION	0.330	Inavolisib	— uncovered
MYOGENESIS	0.250	Inavolisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.210	Inavolisib	— uncovered
UV_RESPONSE_DN	0.190	Inavolisib	— uncovered
MITOTIC_SPINDLE	0.180	Inavolisib	— uncovered
PROTEIN_SECRETION	0.140	Remibrutinib	— uncovered
HEDGEHOG_SIGNALING	0.130	Inavolisib	— uncovered
HYPOXIA	0.120	Idelalisib	— uncovered
COAGULATION	0.110	Binimetinib	— uncovered
CHOLESTEROL_HOMEOSTASIS	0.100	Remibrutinib	— uncovered
APICAL_SURFACE	0.080	Temsirolimus	— uncovered
UNFOLDED_PROTEIN_RESPONSE	0.020	Idelalisib	— uncovered
HEME_METABOLISM	0.010	Temsirolimus	— uncovered