MBCProject_0044_T1_RNA
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.470
- HEDGEHOG_SIGNALING+0.370
- UV_RESPONSE_DN+0.370
- WNT_BETA_CATENIN_SIGNALING+0.330
- ANGIOGENESIS+0.310
- TGF_BETA_SIGNALING+0.290
- MITOTIC_SPINDLE+0.280
- APICAL_JUNCTION+0.220
- MYOGENESIS+0.170
- NOTCH_SIGNALING+0.150
Top 10 suppressed
- MYC_TARGETS_V1-0.420
- MTORC1_SIGNALING-0.410
- OXIDATIVE_PHOSPHORYLATION-0.410
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.390
- ALLOGRAFT_REJECTION-0.360
- INTERFERON_ALPHA_RESPONSE-0.360
- INTERFERON_GAMMA_RESPONSE-0.340
- MYC_TARGETS_V2-0.300
- IL6_JAK_STAT3_SIGNALING-0.290
- ADIPOGENESIS-0.260
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-D8-A1XB-01A-11R-A14D-07 | — | A | 0.874 |
| 2 | ERR2208936 | — | — | 0.865 |
| 3 | SRR6013521 | — | cohortA1 | 0.849 |
| 4 | X8de42096.ef3e.4864.8ee1.2ee7672c1c82 | — | cohortSQ1 | 0.848 |
| 5 | 7900174d-af00-444f-a5b2-226a45f7e76a | — | — | 0.840 |
| 6 | SRR8613779 | — | D | 0.838 |
| 7 | f825534d-5882-4efe-a32e-af56741854f6 | — | — | 0.833 |
| 8 | 20140156.TNBC | — | D | 0.829 |
| 9 | TCGA-56-8626-01A-11R-2403-07 | — | cohortSQ1 | 0.818 |
| 10 | SRR8613798 | — | D | 0.818 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.470 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.370 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.370 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.330 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.310 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.290 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.280 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.220 | Inavolisib | — uncovered |
| MYOGENESIS | 0.170 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.150 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.130 | Temsirolimus | — uncovered |
| PANCREAS_BETA_CELLS | 0.060 | Cobimetinib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.060 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.030 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.030 | Inavolisib | — uncovered |