SRR8518365
— · E
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- E
- subtype
- E
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.520
- MYC_TARGETS_V1+0.400
- E2F_TARGETS+0.270
- UNFOLDED_PROTEIN_RESPONSE+0.110
- G2M_CHECKPOINT+0.100
- NOTCH_SIGNALING+0.100
- WNT_BETA_CATENIN_SIGNALING+0.090
- MITOTIC_SPINDLE+0.060
- DNA_REPAIR+0.050
- OXIDATIVE_PHOSPHORYLATION+0.030
Top 10 suppressed
- INTERFERON_GAMMA_RESPONSE-0.570
- ALLOGRAFT_REJECTION-0.540
- INTERFERON_ALPHA_RESPONSE-0.510
- IL6_JAK_STAT3_SIGNALING-0.490
- INFLAMMATORY_RESPONSE-0.490
- COMPLEMENT-0.480
- COAGULATION-0.410
- IL2_STAT5_SIGNALING-0.360
- ANGIOGENESIS-0.350
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2208946 | — | — | 0.947 |
| 2 | SRR12696755 | — | — | 0.925 |
| 3 | SRR2932822 | — | — | 0.916 |
| 4 | BS_K25F4J3V | ATRT | — | 0.916 |
| 5 | TCGA-QK-A8Z7-01A-11R-A39I-07 | — | — | 0.915 |
| 6 | C3N-02283 | — | cohortMD1 | 0.913 |
| 7 | TCGA-AN-A0AR-01A-11R-A00Z-07 | — | E | 0.912 |
| 8 | s_150324_3a | EPN | Posterior Fossa EPN | 0.911 |
| 9 | SRR8518301 | — | E | 0.911 |
| 10 | SRR5088819 | — | — | 0.911 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.520 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.400 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.270 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.110 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.100 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.100 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.090 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.060 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.050 | Idelalisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.030 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.030 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.010 | Inavolisib | — uncovered |