Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

C3N-03425

· cohortSQ1

0e62852c-0add-5157-9658-f4d33f5021b4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSQ1
subtype
cohortSQ1
age_years
64.54209446

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C3N-03051
lung-landscapes@6
cohortSQ10.886
2SRR8942992
bladder-landscape@3
0.859
3TCGA-G2-A2ES-01A-11R-A180-07
bladder-landscape@3
0.846
4BS_996ZS2A4
brain-umap@2
ATRT0.842
5TCGA-XF-A8HE-01A-11R-A36F-07
bladder-landscape@3
0.838
6R261
bladder-landscape@3
0.828
7BS_S5P8VTN5
brain-umap@2
high-grade glioma0.822
8TCGA-63-A5MR-01A-31R-A27Q-07
lung-landscapes@6
cohortSQ10.821
9TCGA-EW-A1P4-01A-21R-A144-07
breast-umap@18
E0.821
10TCGA-E2-A14Y-01A-21R-A12D-07
breast-umap@18
E0.817

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.550Inavolisib— uncovered
MYC_TARGETS_V20.510Idelalisib— uncovered
MTORC1_SIGNALING0.500Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.480Inavolisib— uncovered
G2M_CHECKPOINT0.460Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.430Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.430Idelalisib— uncovered
E2F_TARGETS0.420Inavolisib— uncovered
MYC_TARGETS_V10.370Inavolisib— uncovered
APICAL_SURFACE0.340Temsirolimus— uncovered
CHOLESTEROL_HOMEOSTASIS0.320Remibrutinib— uncovered
ESTROGEN_RESPONSE_LATE0.300Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.300Inavolisib— uncovered
KRAS_SIGNALING_DN0.290Remibrutinib— uncovered
P53_PATHWAY0.260Idelalisib— uncovered
GLYCOLYSIS0.250Inavolisib— uncovered
APOPTOSIS0.240Idelalisib— uncovered
HYPOXIA0.240Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.240Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.220Remibrutinib— uncovered