Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-EW-A1P4-01A-21R-A144-07

· E

71d5cbc7-9f12-5a80-8aa4-240bff6d38de

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
E
subtype
E
overall_survival_months
30

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.560
  • E2F_TARGETS+0.540
  • G2M_CHECKPOINT+0.540
  • IL6_JAK_STAT3_SIGNALING+0.480
  • INFLAMMATORY_RESPONSE+0.460
  • TNFA_SIGNALING_VIA_NFKB+0.460
  • INTERFERON_GAMMA_RESPONSE+0.450
  • MYC_TARGETS_V2+0.440
  • MTORC1_SIGNALING+0.410
  • MYC_TARGETS_V1+0.400

Top 10 suppressed

  • PROTEIN_SECRETION-0.240
  • BILE_ACID_METABOLISM-0.190
  • ESTROGEN_RESPONSE_EARLY-0.170
  • PEROXISOME-0.140
  • HEME_METABOLISM-0.100
  • HEDGEHOG_SIGNALING-0.090
  • ADIPOGENESIS-0.080
  • FATTY_ACID_METABOLISM-0.080
  • MYOGENESIS-0.070
  • XENOBIOTIC_METABOLISM-0.070

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR35579821
breast-umap@18
E0.918
2TCGA-BH-A0B3-01A-11R-A056-07
breast-umap@18
E0.892
3R398
bladder-landscape@3
0.885
4TCGA-OR-A5JB-01
acc-tcga-pancan-2018@2018
Adrenocortical CarcinomaAdrenocortical Carcinoma, Usual Type0.877
5SRR1516055
bladder-landscape@3
0.875
6TCGA-BH-A1F6-01A-11R-A13Q-07
breast-umap@18
E0.875
7TCGA-66-2755-01A-01R-0851-07
lung-landscapes@6
cohortSQ10.872
8SRR1516056
bladder-landscape@3
0.872
96e639239-cdae-4412-880f-ef813a956ff7
colon-landscapes@1
0.870
1020050099.TNBC
breast-umap@18
D0.866

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.560Idelalisib— uncovered
E2F_TARGETS0.540Inavolisib— uncovered
G2M_CHECKPOINT0.540Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.480Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.460Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.460Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.450Idelalisib— uncovered
MYC_TARGETS_V20.440Idelalisib— uncovered
MTORC1_SIGNALING0.410Inavolisib— uncovered
MYC_TARGETS_V10.400Inavolisib— uncovered
HYPOXIA0.360Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.360Inavolisib— uncovered
GLYCOLYSIS0.330Inavolisib— uncovered
MITOTIC_SPINDLE0.330Inavolisib— uncovered
COMPLEMENT0.320Inavolisib— uncovered
IL2_STAT5_SIGNALING0.320Idelalisib— uncovered
KRAS_SIGNALING_UP0.320Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.310Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.260Inavolisib— uncovered
NOTCH_SIGNALING0.230Inavolisib— uncovered