0f055e01-74ea-4e11-8e8f-8c22b3048875
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ALLOGRAFT_REJECTION+0.500
- COMPLEMENT+0.200
- IL2_STAT5_SIGNALING+0.200
- IL6_JAK_STAT3_SIGNALING+0.200
- INFLAMMATORY_RESPONSE+0.200
- NOTCH_SIGNALING+0.200
- HEME_METABOLISM+0.100
- INTERFERON_GAMMA_RESPONSE+0.100
- P53_PATHWAY+0.100
- PI3K_AKT_MTOR_SIGNALING+0.100
Top 10 suppressed
- CHOLESTEROL_HOMEOSTASIS-0.400
- E2F_TARGETS-0.300
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.300
- ESTROGEN_RESPONSE_LATE-0.300
- FATTY_ACID_METABOLISM-0.300
- G2M_CHECKPOINT-0.300
- GLYCOLYSIS-0.300
- BILE_ACID_METABOLISM-0.200
- COAGULATION-0.200
- HYPOXIA-0.200
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202436 | — | — | 0.757 |
| 2 | 20110029.TNBC | — | D | 0.750 |
| 3 | SRR2932836 | — | — | 0.716 |
| 4 | AUR-AER7-TTP1-A-1-0-R-A741-41 | — | D | 0.707 |
| 5 | s0112296 | — | — | 0.693 |
| 6 | MNG991 | — | — | 0.693 |
| 7 | s0122234 | — | — | 0.691 |
| 8 | SRR8942993 | — | — | 0.690 |
| 9 | ERR4976618 | — | D | 0.684 |
| 10 | TCGA-AO-A0JG-01A-31R-A084-07 | — | A | 0.678 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ALLOGRAFT_REJECTION | 0.500 | Idelalisib | — uncovered |
| COMPLEMENT | 0.200 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.200 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.200 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.200 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.200 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.100 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.100 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.100 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.100 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.100 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.100 | Inavolisib | — uncovered |