s0122234
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ALLOGRAFT_REJECTION+0.400
- IL6_JAK_STAT3_SIGNALING+0.200
- INTERFERON_GAMMA_RESPONSE+0.200
- COMPLEMENT+0.100
- IL2_STAT5_SIGNALING+0.100
- KRAS_SIGNALING_UP+0.100
- UV_RESPONSE_DN+0.100
- APICAL_JUNCTION+0.000
- HEME_METABOLISM+0.000
- INFLAMMATORY_RESPONSE+0.000
Top 10 suppressed
- MYC_TARGETS_V2-0.600
- CHOLESTEROL_HOMEOSTASIS-0.500
- E2F_TARGETS-0.500
- G2M_CHECKPOINT-0.500
- MTORC1_SIGNALING-0.500
- MYC_TARGETS_V1-0.500
- OXIDATIVE_PHOSPHORYLATION-0.500
- DNA_REPAIR-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- GLYCOLYSIS-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2208899 | — | — | 0.902 |
| 2 | X65f5effa.07f7.4ed3.9e0a.3a0d9d451474 | — | cohortA1 | 0.899 |
| 3 | 6b907244-c173-4e29-a163-24258a430477 | — | — | 0.893 |
| 4 | s0112296 | — | — | 0.888 |
| 5 | 20030061.LumA | — | A | 0.888 |
| 6 | TCGA-93-A4JO-01A-21R-A24X-07 | — | cohortA1 | 0.885 |
| 7 | SRR8518276 | — | A | 0.882 |
| 8 | ERR2208971 | — | — | 0.880 |
| 9 | be8d8236-4ebc-46de-a4fd-a901fec1cdce | — | — | 0.875 |
| 10 | SRR12696778 | — | — | 0.872 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ALLOGRAFT_REJECTION | 0.400 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.200 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.200 | Idelalisib | — uncovered |
| COMPLEMENT | 0.100 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.100 | Idelalisib | — uncovered |
| KRAS_SIGNALING_UP | 0.100 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.100 | Inavolisib | — uncovered |