Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_KF0ZXDER

Meningioma

12bd6e76-9d95-56eb-a815-79d6f85ba222

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Meningioma
cancer_type_detailed
subtype
cancer_type
Meningioma
overall_survival_months
52.135348226018394
age_years
17.019
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.536
  • INTERFERON_GAMMA_RESPONSE+0.476
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.429
  • TNFA_SIGNALING_VIA_NFKB+0.426
  • TGF_BETA_SIGNALING+0.419
  • INFLAMMATORY_RESPONSE+0.415
  • ALLOGRAFT_REJECTION+0.394
  • ANDROGEN_RESPONSE+0.382
  • IL6_JAK_STAT3_SIGNALING+0.375
  • APOPTOSIS+0.372

Top 10 suppressed

  • G2M_CHECKPOINT-0.320
  • E2F_TARGETS-0.316
  • HEDGEHOG_SIGNALING-0.314
  • SPERMATOGENESIS-0.277
  • WNT_BETA_CATENIN_SIGNALING-0.220
  • PANCREAS_BETA_CELLS-0.183
  • MITOTIC_SPINDLE-0.163
  • MYC_TARGETS_V2-0.104
  • DNA_REPAIR-0.065
  • KRAS_SIGNALING_UP+0.064

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

1 twin match this tumor's tissue · 9 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_SQX5E15Z
brain-umap@2
pilocytic astrocytoma0.927
2BS_T0RKFEKR
brain-umap@2
pilocytic astrocytoma0.922
3SJEPD031285_D1.RNA-Seq
medullo-epn-umap@date-based
EPNEPN Tumor0.899
4BS_53CTGDQG
brain-umap@2
Meningioma0.896
5BS_HX0S30NE
brain-umap@2
pilocytic astrocytoma0.892
6BS_8J3B6ZB6
brain-umap@2
pilocytic astrocytoma0.889
7SRR660895
brain-umap@2
GTEX0.887
8BS_MBSTWZA6
brain-umap@2
pilocytic astrocytoma0.886
9BS_M4TTKPNR
brain-umap@2
pilocytic astrocytoma0.886
10SRR1388007
brain-umap@2
GTEX0.885

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.536Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.476Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.429Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.426Inavolisib— uncovered
TGF_BETA_SIGNALING0.419Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.415Idelalisib— uncovered
ALLOGRAFT_REJECTION0.394Idelalisib— uncovered
ANDROGEN_RESPONSE0.382Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.375Inavolisib— uncovered
APOPTOSIS0.372Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.365Remibrutinib— uncovered
ANGIOGENESIS0.361Remibrutinib— uncovered
P53_PATHWAY0.350Idelalisib— uncovered
COAGULATION0.336Binimetinib— uncovered
APICAL_SURFACE0.332Temsirolimus— uncovered
UV_RESPONSE_DN0.314Inavolisib— uncovered
PROTEIN_SECRETION0.311Remibrutinib— uncovered
MYOGENESIS0.292Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.284Remibrutinib— uncovered
ADIPOGENESIS0.278Inavolisib— uncovered