s0094236
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.600
- G2M_CHECKPOINT+0.500
- MYC_TARGETS_V1+0.400
- MYC_TARGETS_V2+0.400
- DNA_REPAIR+0.300
- MITOTIC_SPINDLE+0.300
- OXIDATIVE_PHOSPHORYLATION+0.300
- UNFOLDED_PROTEIN_RESPONSE+0.300
- FATTY_ACID_METABOLISM+0.200
- MTORC1_SIGNALING+0.200
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- INTERFERON_ALPHA_RESPONSE-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- ANGIOGENESIS-0.300
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.300
- IL2_STAT5_SIGNALING-0.300
- KRAS_SIGNALING_UP-0.300
- PANCREAS_BETA_CELLS-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR2208894 | — | — | 0.927 |
| 2 | TCGA-46-3768-01A-01R-0980-07 | — | cohortSQ2 | 0.925 |
| 3 | TCGA-AN-A0AK-01A-21R-A00Z-07 | — | C | 0.912 |
| 4 | SRR5088859 | — | — | 0.912 |
| 5 | 1764b9ab-4f37-47c5-8225-40c574433f40 | — | — | 0.905 |
| 6 | TCGA-94-7557-01A-11R-2125-07 | — | cohortMD1 | 0.902 |
| 7 | TCGA-DQ-7588-01A-11R-2081-07 | — | — | 0.901 |
| 8 | TCGA-85-8070-01A-11R-2247-07 | — | cohortSQ2 | 0.901 |
| 9 | e235012b-4b29-478a-abad-6a70cd949cfa | — | — | 0.899 |
| 10 | TCGA-77-8143-01A-11R-2247-07 | — | cohortSQ1 | 0.897 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 22 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.600 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.500 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.400 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.400 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.300 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.300 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.300 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.300 | Idelalisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.200 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.200 | Inavolisib | — uncovered |
| PEROXISOME | 0.200 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.200 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.200 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.100 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.100 | Remibrutinib | — uncovered |
| GLYCOLYSIS | 0.100 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| NOTCH_SIGNALING | 0.100 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.100 | Remibrutinib | — uncovered |