e235012b-4b29-478a-abad-6a70cd949cfa
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 70
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | a8ce7460-8ccd-4638-a854-55c4068af6ec | — | — | 0.927 |
| 2 | TCGA-33-4532-01A-01R-1201-07 | — | cohortSQ2 | 0.922 |
| 3 | TCGA-85-8354-01A-31R-2326-07 | — | cohortSQ2 | 0.913 |
| 4 | TCGA-85-8070-01A-11R-2247-07 | — | cohortSQ2 | 0.913 |
| 5 | TCGA-60-2722-01A-01R-0851-07 | — | cohortSQ2 | 0.908 |
| 6 | TCGA-94-8035-01A-11R-2247-07 | — | cohortSQ1 | 0.907 |
| 7 | TCGA-33-A4WN-01A-11R-A262-07 | — | cohortSQ2 | 0.902 |
| 8 | TCGA-77-8143-01A-11R-2247-07 | — | cohortSQ1 | 0.900 |
| 9 | s0094236 | — | — | 0.899 |
| 10 | TCGA-77-6845-01A-11R-1949-07 | — | cohortSQ2 | 0.898 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 23 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.620 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.570 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.540 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.480 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.390 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.370 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.340 | Idelalisib | — uncovered |
| PEROXISOME | 0.330 | Idelalisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.310 | Remibrutinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.310 | Remibrutinib | — uncovered |
| GLYCOLYSIS | 0.280 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.280 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.160 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.160 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.150 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.150 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.130 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.100 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.080 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.060 | Inavolisib | — uncovered |