Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-B6-A0IE-01A-11R-A034-07

· B

156ac2d5-3c40-538b-834e-2e8c3a1e4424

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
66

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.410
  • ESTROGEN_RESPONSE_EARLY+0.340
  • PANCREAS_BETA_CELLS+0.340
  • ESTROGEN_RESPONSE_LATE+0.320
  • MYC_TARGETS_V1+0.310
  • DNA_REPAIR+0.240
  • OXIDATIVE_PHOSPHORYLATION+0.230
  • UNFOLDED_PROTEIN_RESPONSE+0.200
  • FATTY_ACID_METABOLISM+0.170
  • PEROXISOME+0.170

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.490
  • INFLAMMATORY_RESPONSE-0.480
  • IL6_JAK_STAT3_SIGNALING-0.470
  • INTERFERON_GAMMA_RESPONSE-0.470
  • TNFA_SIGNALING_VIA_NFKB-0.470
  • HEDGEHOG_SIGNALING-0.430
  • ALLOGRAFT_REJECTION-0.400
  • MITOTIC_SPINDLE-0.380
  • KRAS_SIGNALING_UP-0.350
  • UV_RESPONSE_DN-0.340

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-OL-A66O-01A-11R-A31O-07
breast-umap@18
B0.870
2SRR12202489
bladder-landscape@3
0.851
3TCGA-37-5819-01A-01R-1635-07
lung-landscapes@6
cohortA30.844
4TCGA-5T-A9QA-01A-11R-A41B-07
breast-umap@18
B0.842
585d43afd-9aac-48ca-a9c4-00357b7207e1
melanoma-umap@29
0.838
6TCGA-JL-A3YX-01A-11R-A22U-07
breast-umap@18
B0.836
720120289.LumB
breast-umap@18
B0.836
8TCGA-AO-A0J7-01A-11R-A034-07
breast-umap@18
B0.833
9TCGA-B6-A0IB-01A-11R-A034-07
breast-umap@18
B0.833
10a9e8b311-dfde-4c34-80a2-5e64f94c596b
melanoma-umap@29
0.829

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 18 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.410Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.340Inavolisib— uncovered
PANCREAS_BETA_CELLS0.340Cobimetinib— uncovered
ESTROGEN_RESPONSE_LATE0.320Idelalisib— uncovered
MYC_TARGETS_V10.310Inavolisib— uncovered
DNA_REPAIR0.240Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.230Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.200Idelalisib— uncovered
FATTY_ACID_METABOLISM0.170Inavolisib— uncovered
PEROXISOME0.170Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.160Inavolisib— uncovered
KRAS_SIGNALING_DN0.150Remibrutinib— uncovered
ADIPOGENESIS0.100Inavolisib— uncovered
E2F_TARGETS0.080Inavolisib— uncovered
MYOGENESIS0.050Inavolisib— uncovered
G2M_CHECKPOINT0.040Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.040Inavolisib— uncovered
MTORC1_SIGNALING0.020Inavolisib— uncovered