Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-OL-A66O-01A-11R-A31O-07

· B

ba0b01d3-0eb5-51ff-95c4-c37c428a7ea2

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
18

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V2+0.420
  • DNA_REPAIR+0.360
  • ESTROGEN_RESPONSE_LATE+0.360
  • OXIDATIVE_PHOSPHORYLATION+0.340
  • ESTROGEN_RESPONSE_EARLY+0.330
  • KRAS_SIGNALING_DN+0.230
  • MYC_TARGETS_V1+0.200
  • BILE_ACID_METABOLISM+0.190
  • E2F_TARGETS+0.190
  • MYOGENESIS+0.160

Top 10 suppressed

  • PROTEIN_SECRETION-0.470
  • INFLAMMATORY_RESPONSE-0.450
  • HEDGEHOG_SIGNALING-0.430
  • IL6_JAK_STAT3_SIGNALING-0.430
  • KRAS_SIGNALING_UP-0.430
  • ALLOGRAFT_REJECTION-0.410
  • UV_RESPONSE_DN-0.400
  • INTERFERON_GAMMA_RESPONSE-0.380
  • MITOTIC_SPINDLE-0.360
  • COMPLEMENT-0.350

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-B6-A0IE-01A-11R-A034-07
breast-umap@18
B0.870
2TCGA-E2-A576-01A-11R-A31O-07
breast-umap@18
B0.865
3TCGA-JL-A3YX-01A-11R-A22U-07
breast-umap@18
B0.854
4TCGA-E9-A54Y-01A-11R-A466-07
breast-umap@18
B0.853
5TCGA-CQ-A4C9-01A-11R-A24Z-07
head-neck@1
0.842
6SJEPD001539_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.841
7TCGA-AC-A62V-01A-11R-A31O-07
breast-umap@18
B0.833
885d43afd-9aac-48ca-a9c4-00357b7207e1
melanoma-umap@29
0.831
9TCGA-LL-A5YM-01A-11R-A28M-07
breast-umap@18
B0.823
10TCGA-MZ-A6I9-01A-11R-A31N-07
head-neck@1
0.821

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 19 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V20.420Idelalisib— uncovered
DNA_REPAIR0.360Idelalisib— uncovered
ESTROGEN_RESPONSE_LATE0.360Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.340Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.330Inavolisib— uncovered
KRAS_SIGNALING_DN0.230Remibrutinib— uncovered
MYC_TARGETS_V10.200Inavolisib— uncovered
BILE_ACID_METABOLISM0.190Inavolisib— uncovered
E2F_TARGETS0.190Inavolisib— uncovered
MYOGENESIS0.160Inavolisib— uncovered
APICAL_SURFACE0.140Temsirolimus— uncovered
PEROXISOME0.140Idelalisib— uncovered
FATTY_ACID_METABOLISM0.120Inavolisib— uncovered
GLYCOLYSIS0.120Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.050Inavolisib— uncovered
SPERMATOGENESIS0.040Inavolisib— uncovered
COAGULATION0.030Binimetinib— uncovered
PANCREAS_BETA_CELLS0.030Cobimetinib— uncovered
UV_RESPONSE_UP0.030Idelalisib— uncovered