SRR1489054
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.182
- DNA_REPAIR+0.092
- WNT_BETA_CATENIN_SIGNALING+0.045
- SPERMATOGENESIS+0.006
- PI3K_AKT_MTOR_SIGNALING-0.003
- MITOTIC_SPINDLE-0.004
- UV_RESPONSE_UP-0.016
- MYC_TARGETS_V2-0.046
- HEME_METABOLISM-0.047
- MYOGENESIS-0.053
Top 10 suppressed
- ANGIOGENESIS-0.529
- INTERFERON_ALPHA_RESPONSE-0.512
- INFLAMMATORY_RESPONSE-0.475
- INTERFERON_GAMMA_RESPONSE-0.464
- TNFA_SIGNALING_VIA_NFKB-0.442
- TGF_BETA_SIGNALING-0.428
- ALLOGRAFT_REJECTION-0.413
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.409
- COMPLEMENT-0.404
- APOPTOSIS-0.399
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1322010 | GTEX | — | 0.978 |
| 2 | SRR1377984 | GTEX | — | 0.974 |
| 3 | SRR1364800 | GTEX | — | 0.971 |
| 4 | SRR1453214 | GTEX | — | 0.971 |
| 5 | SRR1434271 | GTEX | — | 0.970 |
| 6 | SRR1394936 | GTEX | — | 0.970 |
| 7 | SRR1322291 | GTEX | — | 0.969 |
| 8 | SRR1459033 | GTEX | — | 0.969 |
| 9 | SRR1327811 | GTEX | — | 0.969 |
| 10 | SRR1441224 | GTEX | — | 0.969 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.182 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.092 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.045 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.006 | Inavolisib | — uncovered |