Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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SRR1441224

GTEX

cd27a3fa-8f12-51bd-98bb-e597db09468e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • DNA_REPAIR+0.124
  • MITOTIC_SPINDLE+0.060
  • KRAS_SIGNALING_DN+0.034
  • MYC_TARGETS_V2-0.009
  • UNFOLDED_PROTEIN_RESPONSE-0.020
  • SPERMATOGENESIS-0.048
  • WNT_BETA_CATENIN_SIGNALING-0.049
  • PI3K_AKT_MTOR_SIGNALING-0.059
  • MYC_TARGETS_V1-0.065
  • PEROXISOME-0.069

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.590
  • TNFA_SIGNALING_VIA_NFKB-0.548
  • INFLAMMATORY_RESPONSE-0.535
  • INTERFERON_GAMMA_RESPONSE-0.520
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.509
  • IL6_JAK_STAT3_SIGNALING-0.498
  • ALLOGRAFT_REJECTION-0.483
  • ANGIOGENESIS-0.476
  • COAGULATION-0.468
  • APOPTOSIS-0.460

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1359367
brain-umap@2
GTEX0.988
2SRR1319672
brain-umap@2
GTEX0.987
3SRR1419675
brain-umap@2
GTEX0.987
4SRR1464305
brain-umap@2
GTEX0.987
5SRR820468
brain-umap@2
GTEX0.986
6SRR1477385
brain-umap@2
GTEX0.986
7SRR1356204
brain-umap@2
GTEX0.986
8SRR807657
brain-umap@2
GTEX0.985
9SRR1490568
brain-umap@2
GTEX0.985
10SRR1352415
brain-umap@2
GTEX0.984

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 3 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
DNA_REPAIR0.124Idelalisib— uncovered
MITOTIC_SPINDLE0.060Inavolisib— uncovered
KRAS_SIGNALING_DN0.034Remibrutinib— uncovered