SRR25043615
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- TGF_BETA_SIGNALING+0.350
- MYOGENESIS+0.280
- P53_PATHWAY+0.220
- WNT_BETA_CATENIN_SIGNALING+0.210
- HEME_METABOLISM+0.140
- PROTEIN_SECRETION+0.120
- APICAL_JUNCTION+0.100
- NOTCH_SIGNALING+0.090
- UV_RESPONSE_DN+0.050
- ESTROGEN_RESPONSE_EARLY+0.020
Top 10 suppressed
- E2F_TARGETS-0.590
- G2M_CHECKPOINT-0.480
- MYC_TARGETS_V2-0.440
- INTERFERON_GAMMA_RESPONSE-0.380
- ALLOGRAFT_REJECTION-0.370
- INTERFERON_ALPHA_RESPONSE-0.350
- INFLAMMATORY_RESPONSE-0.310
- ANGIOGENESIS-0.300
- MTORC1_SIGNALING-0.300
- CHOLESTEROL_HOMEOSTASIS-0.280
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1516060 | — | — | 0.864 |
| 2 | TCGA-BH-A0DO-01B-11R-A12D-07 | — | A | 0.858 |
| 3 | TCGA-55-8097-01A-11R-2241-07 | — | cohortA1 | 0.857 |
| 4 | GSM5359413 | — | — | 0.838 |
| 5 | SRR27320668 | — | — | 0.834 |
| 6 | SRR1313106 | — | B | 0.832 |
| 7 | SRR1516046 | — | — | 0.832 |
| 8 | TCGA-AN-A0XT-01A-11R-A109-07 | — | B | 0.831 |
| 9 | TCGA-B6-A0RQ-01A-11R-A115-07 | — | A | 0.828 |
| 10 | TCGA-55-8087-01A-11R-2241-07 | — | cohortA1 | 0.827 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| TGF_BETA_SIGNALING | 0.350 | Inavolisib | — uncovered |
| MYOGENESIS | 0.280 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.220 | Idelalisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.210 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.140 | Temsirolimus | — uncovered |
| PROTEIN_SECRETION | 0.120 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.100 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.090 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.050 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.020 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.010 | Inavolisib | — uncovered |
| PEROXISOME | 0.010 | Idelalisib | — uncovered |