Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · breast-umap@18

SRR25617878

— · D

19c694c1-4d05-5431-ac09-f9dce6239716

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
—
cancer_type_detailed
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subtype
D
subtype
D

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-AR-A1AO-01A-11R-A12P-07
breast-umap@18
—A0.877
2TCGA-E2-A1B5-01A-21R-A12P-07
breast-umap@18
—D0.869
3BS_KX6J8TRK
brain-umap@2
pilocytic astrocytoma—0.864
4ERR2208891
melanoma-umap@29
——0.858
574cffe84-dca8-4673-925a-9e0d6344832a
melanoma-umap@29
——0.855
6SRR35579799
breast-umap@18
—D0.843
72833b2f4-e943-4570-96c2-a42c127cd1fa
melanoma-umap@29
——0.843
820060029.TNBC
breast-umap@18
—D0.842
9TCGA-BH-A0B6-01A-11R-A19W-07
breast-umap@18
—D0.838
10SRR5088860
melanoma-umap@29
——0.832

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 33 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.570Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.500Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.460Idelalisib— uncovered
COMPLEMENT0.440Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.420Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.420Inavolisib— uncovered
KRAS_SIGNALING_UP0.370Inavolisib— uncovered
IL2_STAT5_SIGNALING0.360Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.360Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.360Inavolisib— uncovered
PANCREAS_BETA_CELLS0.300Cobimetinib— uncovered
ADIPOGENESIS0.270Inavolisib— uncovered
COAGULATION0.260Binimetinib— uncovered
APOPTOSIS0.240Idelalisib— uncovered
HYPOXIA0.230Idelalisib— uncovered
FATTY_ACID_METABOLISM0.210Inavolisib— uncovered
P53_PATHWAY0.210Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.210Inavolisib— uncovered
UV_RESPONSE_UP0.190Idelalisib— uncovered
BILE_ACID_METABOLISM0.180Inavolisib— uncovered