Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

AUR-AFKF-TTM1-A-1-1-R-A742-41

· C

1add436c-6cc4-51a6-aab0-b357477c8c63

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.530
  • DNA_REPAIR+0.400
  • MYC_TARGETS_V1+0.290
  • ADIPOGENESIS+0.240
  • E2F_TARGETS+0.240
  • PROTEIN_SECRETION+0.230
  • MYC_TARGETS_V2+0.220
  • MTORC1_SIGNALING+0.200
  • PEROXISOME+0.200
  • FATTY_ACID_METABOLISM+0.180

Top 10 suppressed

  • INFLAMMATORY_RESPONSE-0.450
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.440
  • TNFA_SIGNALING_VIA_NFKB-0.430
  • INTERFERON_GAMMA_RESPONSE-0.400
  • TGF_BETA_SIGNALING-0.390
  • ALLOGRAFT_REJECTION-0.380
  • IL6_JAK_STAT3_SIGNALING-0.380
  • INTERFERON_ALPHA_RESPONSE-0.380
  • ANGIOGENESIS-0.360
  • APICAL_SURFACE-0.330

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR8518448
breast-umap@18
C0.910
2TCGA-CQ-6225-01A-11R-1915-07
head-neck@1
0.904
3MNG87
mng-umap@100
0.903
4SRR12475110
colon-landscapes@1
0.901
5SRR1797243
lung-landscapes@6
cohortSC0.896
6TCGA-A8-A06Z-01A-11R-A00Z-07
breast-umap@18
B0.892
7C3L-00993
lung-landscapes@6
cohortSQ10.890
8BSR_20_0054redo_S62
breast-umap@18
B0.890
9513fb61a-1339-45d2-8963-6337e3aff5df
colon-landscapes@1
0.889
10TCGA-66-2756-01A-01R-0851-07
lung-landscapes@6
cohortA30.888

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 17 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.530Remibrutinib— uncovered
DNA_REPAIR0.400Idelalisib— uncovered
MYC_TARGETS_V10.290Inavolisib— uncovered
ADIPOGENESIS0.240Inavolisib— uncovered
E2F_TARGETS0.240Inavolisib— uncovered
PROTEIN_SECRETION0.230Remibrutinib— uncovered
MYC_TARGETS_V20.220Idelalisib— uncovered
MTORC1_SIGNALING0.200Inavolisib— uncovered
PEROXISOME0.200Idelalisib— uncovered
FATTY_ACID_METABOLISM0.180Inavolisib— uncovered
SPERMATOGENESIS0.180Inavolisib— uncovered
GLYCOLYSIS0.160Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.140Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.120Inavolisib— uncovered
BILE_ACID_METABOLISM0.090Inavolisib— uncovered
P53_PATHWAY0.080Idelalisib— uncovered
G2M_CHECKPOINT0.060Inavolisib— uncovered