TCGA-LD-A7W6-01A-81R-A352-07
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
- overall_survival_months
- 13
- os_event
- false
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.510
- WNT_BETA_CATENIN_SIGNALING+0.370
- ESTROGEN_RESPONSE_EARLY+0.160
- INTERFERON_GAMMA_RESPONSE+0.130
- KRAS_SIGNALING_DN+0.120
- ESTROGEN_RESPONSE_LATE+0.090
- NOTCH_SIGNALING+0.080
- MYOGENESIS+0.060
- DNA_REPAIR+0.020
- TGF_BETA_SIGNALING-0.010
Top 10 suppressed
- MTORC1_SIGNALING-0.560
- OXIDATIVE_PHOSPHORYLATION-0.480
- PROTEIN_SECRETION-0.480
- MYC_TARGETS_V1-0.470
- ANGIOGENESIS-0.440
- CHOLESTEROL_HOMEOSTASIS-0.420
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- COMPLEMENT-0.380
- ANDROGEN_RESPONSE-0.370
- GLYCOLYSIS-0.320
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 88448 | EPN | Supratentorial EPN | 0.871 |
| 2 | 20040121.LumB | — | D | 0.852 |
| 3 | SRR4195656 | — | — | 0.832 |
| 4 | SRR33532764 | — | D | 0.829 |
| 5 | SRR650134 | — | — | 0.823 |
| 6 | MBCproject_6016_T1_RNA | — | A | 0.811 |
| 7 | SRR4195673 | — | — | 0.808 |
| 8 | aMVAC.P_002_TURBT_S219 | — | — | 0.800 |
| 9 | SRR1313093 | — | B | 0.797 |
| 10 | MNG961 | — | — | 0.796 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.510 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.370 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.160 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.130 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.120 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.090 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.080 | Inavolisib | — uncovered |
| MYOGENESIS | 0.060 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.020 | Idelalisib | — uncovered |