SRR1313093

— · B

6a08d597-5a29-5d1a-aa22-88d8b5a8d663

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: B
subtype: B

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

ESTROGEN_RESPONSE_EARLY+0.210
MYOGENESIS+0.210
KRAS_SIGNALING_DN+0.090
ESTROGEN_RESPONSE_LATE+0.080
APICAL_JUNCTION-0.010
SPERMATOGENESIS-0.080
WNT_BETA_CATENIN_SIGNALING-0.080
NOTCH_SIGNALING-0.090
P53_PATHWAY-0.090
BILE_ACID_METABOLISM-0.120

Top 10 suppressed

MYC_TARGETS_V1-0.600
MTORC1_SIGNALING-0.520
E2F_TARGETS-0.500
OXIDATIVE_PHOSPHORYLATION-0.470
PROTEIN_SECRETION-0.450
G2M_CHECKPOINT-0.430
ALLOGRAFT_REJECTION-0.400
ANDROGEN_RESPONSE-0.400
FATTY_ACID_METABOLISM-0.380
TGF_BETA_SIGNALING-0.350

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR1313115 breast-umap@18	—	B	0.928
2	TCGA-CU-A3YL-01A-11R-A22U-07 bladder-landscape@3	—	—	0.914
3	SRR1313097 breast-umap@18	—	A	0.909
4	TCGA-W8-A86G-01A-21R-A36F-07 breast-umap@18	—	A	0.893
5	ERR4976607 breast-umap@18	—	B	0.891
6	SRR1404168 brain-umap@2	GTEX	—	0.890
7	TCGA-E7-A3Y1-01A-11R-A22U-07 bladder-landscape@3	—	—	0.889
8	SRR6013520 lung-landscapes@6	—	cohortA1	0.888
9	BS_V7BJM89K brain-umap@2	low-grade glioma	—	0.888
10	BS_90B22NGP brain-umap@2	ATRT	—	0.885

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
ESTROGEN_RESPONSE_EARLY	0.210	Inavolisib	— uncovered
MYOGENESIS	0.210	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.090	Remibrutinib	— uncovered
ESTROGEN_RESPONSE_LATE	0.080	Idelalisib	— uncovered