SRR1435293
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.462
- OXIDATIVE_PHOSPHORYLATION+0.333
- KRAS_SIGNALING_DN+0.328
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.218
- SPERMATOGENESIS+0.200
- MYOGENESIS+0.174
- FATTY_ACID_METABOLISM+0.173
- BILE_ACID_METABOLISM+0.128
- ESTROGEN_RESPONSE_LATE+0.116
- UV_RESPONSE_DN+0.074
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.503
- MYC_TARGETS_V2-0.442
- WNT_BETA_CATENIN_SIGNALING-0.418
- INTERFERON_GAMMA_RESPONSE-0.414
- TGF_BETA_SIGNALING-0.396
- MITOTIC_SPINDLE-0.379
- UNFOLDED_PROTEIN_RESPONSE-0.376
- TNFA_SIGNALING_VIA_NFKB-0.363
- G2M_CHECKPOINT-0.354
- IL6_JAK_STAT3_SIGNALING-0.343
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1312103 | GTEX | — | 0.937 |
| 2 | SRR1381889 | GTEX | — | 0.932 |
| 3 | SRR818418 | GTEX | — | 0.923 |
| 4 | SRR1341763 | GTEX | — | 0.919 |
| 5 | SRR1408368 | GTEX | — | 0.914 |
| 6 | SRR1318426 | GTEX | — | 0.913 |
| 7 | SRR1350456 | GTEX | — | 0.909 |
| 8 | SRR1437306 | GTEX | — | 0.906 |
| 9 | SRR1348339 | GTEX | — | 0.905 |
| 10 | SRR1498640 | GTEX | — | 0.904 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.462 | Cobimetinib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.333 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.328 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.218 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| MYOGENESIS | 0.174 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.173 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.128 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.116 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.074 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.052 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.043 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.041 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.039 | Inavolisib | — uncovered |