SRR1348446
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.286
- PROTEIN_SECRETION+0.235
- MYC_TARGETS_V2+0.214
- UNFOLDED_PROTEIN_RESPONSE+0.189
- DNA_REPAIR+0.185
- MYC_TARGETS_V1+0.152
- HEME_METABOLISM+0.103
- PI3K_AKT_MTOR_SIGNALING+0.094
- PEROXISOME+0.093
- SPERMATOGENESIS+0.007
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.583
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.555
- ANGIOGENESIS-0.520
- INTERFERON_GAMMA_RESPONSE-0.515
- TGF_BETA_SIGNALING-0.479
- INFLAMMATORY_RESPONSE-0.476
- COAGULATION-0.439
- IL6_JAK_STAT3_SIGNALING-0.426
- HEDGEHOG_SIGNALING-0.401
- ALLOGRAFT_REJECTION-0.398
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1407560 | GTEX | — | 0.980 |
| 2 | SRR1377445 | GTEX | — | 0.971 |
| 3 | SRR1403915 | GTEX | — | 0.967 |
| 4 | SRR1441141 | GTEX | — | 0.967 |
| 5 | SRR1410934 | GTEX | — | 0.965 |
| 6 | SRR604098 | GTEX | — | 0.964 |
| 7 | SRR1499442 | GTEX | — | 0.964 |
| 8 | SRR819999 | GTEX | — | 0.964 |
| 9 | SRR1406917 | GTEX | — | 0.962 |
| 10 | SRR656179 | GTEX | — | 0.961 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.286 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.235 | Remibrutinib | — uncovered |
| MYC_TARGETS_V2 | 0.214 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.189 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.185 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.152 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.103 | Temsirolimus | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.094 | Inavolisib | — uncovered |
| PEROXISOME | 0.093 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.007 | Inavolisib | — uncovered |