BS_K74PZET7
medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- medulloblastoma
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- medulloblastoma
- overall_survival_months
- 34.19842312746386
- age_years
- 5.616
- sex
- Female
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_JFB984RG | medulloblastoma | — | 0.986 |
| 2 | BS_Z7PKVY9J | medulloblastoma | — | 0.982 |
| 3 | BS_H4B5Y6S0 | medulloblastoma | — | 0.981 |
| 4 | BS_DFWFBYSN | medulloblastoma | — | 0.980 |
| 5 | BS_HZE3KYZ1 | medulloblastoma | — | 0.979 |
| 6 | BS_HF3RNN2T | medulloblastoma | — | 0.977 |
| 7 | BS_J8G4SH4Z | medulloblastoma | — | 0.975 |
| 8 | BS_GNV89A5P | medulloblastoma | — | 0.974 |
| 9 | BS_KYF0Q0E7 | medulloblastoma | — | 0.972 |
| 10 | BS_BSV07M7Z | medulloblastoma | — | 0.971 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.465 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.448 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.440 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.432 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.415 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.236 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.182 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.161 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.152 | Cobimetinib | — uncovered |
| MITOTIC_SPINDLE | 0.151 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.132 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.029 | Temsirolimus | — uncovered |
| PEROXISOME | 0.019 | Idelalisib | — uncovered |