SRR1415337
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- INTERFERON_ALPHA_RESPONSE+0.555
- INTERFERON_GAMMA_RESPONSE+0.456
- ALLOGRAFT_REJECTION+0.308
- APOPTOSIS+0.288
- IL6_JAK_STAT3_SIGNALING+0.280
- INFLAMMATORY_RESPONSE+0.272
- COMPLEMENT+0.249
- TNFA_SIGNALING_VIA_NFKB+0.233
- BILE_ACID_METABOLISM+0.213
- IL2_STAT5_SIGNALING+0.208
Top 10 suppressed
- HEDGEHOG_SIGNALING-0.398
- PANCREAS_BETA_CELLS-0.325
- UV_RESPONSE_DN-0.236
- SPERMATOGENESIS-0.224
- G2M_CHECKPOINT-0.183
- KRAS_SIGNALING_DN-0.154
- E2F_TARGETS-0.140
- NOTCH_SIGNALING-0.127
- WNT_BETA_CATENIN_SIGNALING-0.115
- ESTROGEN_RESPONSE_EARLY-0.113
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1413768 | GTEX | — | 0.866 |
| 2 | SRR1085015 | GTEX | — | 0.861 |
| 3 | BS_H3Y8FWHV | Schwannoma | — | 0.860 |
| 4 | BS_1SVVER1H | Schwannoma | — | 0.859 |
| 5 | SRR1402882 | GTEX | — | 0.854 |
| 6 | SRR1446828 | GTEX | — | 0.851 |
| 7 | 80B61352-E9FC-4B3E-BAA8-ECBFD2A6E9B3 | — | — | 0.850 |
| 8 | SRR603397 | GTEX | — | 0.839 |
| 9 | BS_479S95Q6 | Schwannoma | — | 0.839 |
| 10 | SRR1369148 | GTEX | — | 0.837 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 32 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| INTERFERON_ALPHA_RESPONSE | 0.555 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.456 | Idelalisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.308 | Idelalisib | — uncovered |
| APOPTOSIS | 0.288 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.280 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.272 | Idelalisib | — uncovered |
| COMPLEMENT | 0.249 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.233 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.213 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.208 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.202 | Inavolisib | — uncovered |
| COAGULATION | 0.197 | Binimetinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.197 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.187 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.173 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.172 | Idelalisib | — uncovered |
| PEROXISOME | 0.168 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.165 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.165 | Remibrutinib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.159 | Inavolisib | — uncovered |