SRR1085015
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- COMPLEMENT+0.353
- INTERFERON_GAMMA_RESPONSE+0.336
- INTERFERON_ALPHA_RESPONSE+0.318
- ALLOGRAFT_REJECTION+0.313
- INFLAMMATORY_RESPONSE+0.309
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.238
- TGF_BETA_SIGNALING+0.237
- IL2_STAT5_SIGNALING+0.222
- IL6_JAK_STAT3_SIGNALING+0.220
- COAGULATION+0.198
Top 10 suppressed
- NOTCH_SIGNALING-0.347
- HEDGEHOG_SIGNALING-0.333
- PANCREAS_BETA_CELLS-0.323
- G2M_CHECKPOINT-0.276
- E2F_TARGETS-0.228
- UV_RESPONSE_DN-0.164
- MYC_TARGETS_V2-0.122
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.113
- GLYCOLYSIS-0.109
- KRAS_SIGNALING_DN-0.094
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1415337 | GTEX | — | 0.861 |
| 2 | SRR1413768 | GTEX | — | 0.850 |
| 3 | SRR1402840 | GTEX | — | 0.815 |
| 4 | SRR1402882 | GTEX | — | 0.804 |
| 5 | SRR1333694 | GTEX | — | 0.797 |
| 6 | SRR1085782 | GTEX | — | 0.795 |
| 7 | BS_H3Y8FWHV | Schwannoma | — | 0.794 |
| 8 | SRR1429244 | GTEX | — | 0.793 |
| 9 | BS_1SVVER1H | Schwannoma | — | 0.793 |
| 10 | SRR1446828 | GTEX | — | 0.789 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 31 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| COMPLEMENT | 0.353 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.336 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.318 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.313 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.309 | Idelalisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.238 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.237 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.222 | Idelalisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.220 | Inavolisib | — uncovered |
| COAGULATION | 0.198 | Binimetinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.197 | Remibrutinib | — uncovered |
| P53_PATHWAY | 0.193 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.188 | Inavolisib | — uncovered |
| APOPTOSIS | 0.166 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.165 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.160 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.157 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.145 | Remibrutinib | — uncovered |
| MTORC1_SIGNALING | 0.142 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.131 | Inavolisib | — uncovered |