SRR1352129
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.235
- MITOTIC_SPINDLE+0.097
- CHOLESTEROL_HOMEOSTASIS+0.089
- APICAL_JUNCTION+0.073
- KRAS_SIGNALING_DN+0.057
- HEME_METABOLISM-0.014
- APICAL_SURFACE-0.020
- DNA_REPAIR-0.035
- WNT_BETA_CATENIN_SIGNALING-0.045
- PEROXISOME-0.049
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.453
- INTERFERON_GAMMA_RESPONSE-0.419
- COAGULATION-0.409
- TNFA_SIGNALING_VIA_NFKB-0.366
- ALLOGRAFT_REJECTION-0.363
- ANGIOGENESIS-0.360
- TGF_BETA_SIGNALING-0.353
- COMPLEMENT-0.351
- PANCREAS_BETA_CELLS-0.333
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR615249 | GTEX | — | 0.950 |
| 2 | SRR1453214 | GTEX | — | 0.926 |
| 3 | SRR607967 | GTEX | — | 0.925 |
| 4 | SRR1403875 | GTEX | — | 0.925 |
| 5 | SRR1327811 | GTEX | — | 0.923 |
| 6 | SRR1364800 | GTEX | — | 0.921 |
| 7 | SRR1322291 | GTEX | — | 0.919 |
| 8 | SRR1388504 | GTEX | — | 0.917 |
| 9 | SRR1417981 | GTEX | — | 0.916 |
| 10 | SRR1322010 | GTEX | — | 0.915 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.235 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.097 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.089 | Remibrutinib | — uncovered |
| APICAL_JUNCTION | 0.073 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.057 | Remibrutinib | — uncovered |