SRR1417981
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.122
- KRAS_SIGNALING_DN+0.082
- MITOTIC_SPINDLE+0.072
- DNA_REPAIR+0.066
- PI3K_AKT_MTOR_SIGNALING+0.058
- SPERMATOGENESIS+0.033
- APICAL_JUNCTION+0.000
- PEROXISOME-0.003
- UNFOLDED_PROTEIN_RESPONSE-0.004
- WNT_BETA_CATENIN_SIGNALING-0.056
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.576
- INTERFERON_GAMMA_RESPONSE-0.463
- TGF_BETA_SIGNALING-0.435
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.425
- KRAS_SIGNALING_UP-0.416
- ALLOGRAFT_REJECTION-0.411
- INFLAMMATORY_RESPONSE-0.407
- IL6_JAK_STAT3_SIGNALING-0.393
- TNFA_SIGNALING_VIA_NFKB-0.379
- COAGULATION-0.362
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1401062 | GTEX | — | 0.973 |
| 2 | SRR1472193 | GTEX | — | 0.970 |
| 3 | SRR1398839 | GTEX | — | 0.968 |
| 4 | SRR1490568 | GTEX | — | 0.968 |
| 5 | SRR1327811 | GTEX | — | 0.967 |
| 6 | SRR820468 | GTEX | — | 0.966 |
| 7 | SRR1314187 | GTEX | — | 0.966 |
| 8 | SRR1361736 | GTEX | — | 0.966 |
| 9 | SRR1464305 | GTEX | — | 0.965 |
| 10 | SRR1348770 | GTEX | — | 0.965 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.122 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.082 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.072 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.066 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.058 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.033 | Inavolisib | — uncovered |