MNG1106
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.349
- INTERFERON_ALPHA_RESPONSE+0.261
- KRAS_SIGNALING_DN+0.181
- SPERMATOGENESIS+0.175
- INTERFERON_GAMMA_RESPONSE+0.140
- MYOGENESIS+0.113
- BILE_ACID_METABOLISM+0.108
- ESTROGEN_RESPONSE_EARLY+0.073
- XENOBIOTIC_METABOLISM+0.052
- DNA_REPAIR+0.035
Top 10 suppressed
- PROTEIN_SECRETION-0.453
- MYC_TARGETS_V1-0.448
- TGF_BETA_SIGNALING-0.435
- ANGIOGENESIS-0.427
- G2M_CHECKPOINT-0.408
- UV_RESPONSE_DN-0.396
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.394
- ANDROGEN_RESPONSE-0.357
- E2F_TARGETS-0.356
- WNT_BETA_CATENIN_SIGNALING-0.346
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-49-AAQV-01A-11R-A39D-07 | — | cohortA1 | 0.870 |
| 2 | SJEPD019_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.865 |
| 3 | TCGA-AQ-A54O-01A-11R-A266-07 | — | B | 0.848 |
| 4 | SJEPD027_D.RNA-Seq | EPN | Posterior Fossa EPN | 0.842 |
| 5 | SRR6079989 | — | — | 0.836 |
| 6 | R11 | — | — | 0.824 |
| 7 | TCGA-49-AAR2-01A-11R-A39D-07 | — | cohortA3 | 0.821 |
| 8 | TCGA-EW-A423-01A-11R-A24H-07 | — | B | 0.817 |
| 9 | TCGA-E7-A7DU-01A-11R-A32O-07 | — | — | 0.810 |
| 10 | SRR1316921 | GTEX | — | 0.810 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.349 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.261 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.181 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.175 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.140 | Idelalisib | — uncovered |
| MYOGENESIS | 0.113 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.108 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.073 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.052 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.035 | Idelalisib | — uncovered |
| PEROXISOME | 0.034 | Idelalisib | — uncovered |
| APICAL_SURFACE | 0.031 | Temsirolimus | — uncovered |
| HEME_METABOLISM | 0.009 | Temsirolimus | — uncovered |