Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR1316921

GTEX

8b5fc1be-9875-539b-af17-12f333a912eb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PANCREAS_BETA_CELLS+0.336
  • KRAS_SIGNALING_DN+0.274
  • HEDGEHOG_SIGNALING+0.157
  • OXIDATIVE_PHOSPHORYLATION+0.138
  • SPERMATOGENESIS+0.099
  • MYOGENESIS+0.088
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.040
  • ALLOGRAFT_REJECTION+0.024
  • PEROXISOME+0.011
  • APICAL_SURFACE-0.023

Top 10 suppressed

  • TGF_BETA_SIGNALING-0.500
  • G2M_CHECKPOINT-0.484
  • MITOTIC_SPINDLE-0.482
  • E2F_TARGETS-0.445
  • ANGIOGENESIS-0.422
  • MYC_TARGETS_V1-0.378
  • ANDROGEN_RESPONSE-0.366
  • TNFA_SIGNALING_VIA_NFKB-0.347
  • PROTEIN_SECRETION-0.342
  • UV_RESPONSE_DN-0.326

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1319837
brain-umap@2
GTEX0.958
2SRR1311182
brain-umap@2
GTEX0.956
3SRR1319970
brain-umap@2
GTEX0.934
452425995-0bd7-4149-bc2a-26522ebd143d
melanoma-umap@29
0.917
5SRR1414897
brain-umap@2
GTEX0.910
6MDT-AP-2026
medullo-epn-umap@date-based
MedMedulloblastoma0.902
7MNG1089
mng-umap@100
0.899
8d2c9b21d-0f64-4182-9d5d-82b80a158a1f
melanoma-umap@29
0.899
94e64826b-fffb-4430-bc34-ea6086e89a0a
melanoma-umap@29
0.898
10SJEPD007_D.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.894

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 9 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PANCREAS_BETA_CELLS0.336Cobimetinib— uncovered
KRAS_SIGNALING_DN0.274Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.157Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.138Remibrutinib— uncovered
SPERMATOGENESIS0.099Inavolisib— uncovered
MYOGENESIS0.088Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.040Inavolisib— uncovered
ALLOGRAFT_REJECTION0.024Idelalisib— uncovered
PEROXISOME0.011Idelalisib— uncovered