Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

← Cohorts · brain-umap@2

BS_7G42J2SK

Supratentorial Ependymoma

222a8a90-77ea-5e9c-8364-97fa4150969c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Supratentorial Ependymoma
cancer_type_detailed
—
subtype
—
cancer_type
Supratentorial Ependymoma
overall_survival_months
52.890932982917214
age_years
17.227
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • E2F_TARGETS+0.468
  • PROTEIN_SECRETION+0.414
  • MYC_TARGETS_V1+0.413
  • DNA_REPAIR+0.374
  • G2M_CHECKPOINT+0.350
  • MTORC1_SIGNALING+0.339
  • PI3K_AKT_MTOR_SIGNALING+0.338
  • UNFOLDED_PROTEIN_RESPONSE+0.274
  • OXIDATIVE_PHOSPHORYLATION+0.268
  • MITOTIC_SPINDLE+0.161

Top 10 suppressed

  • APICAL_SURFACE-0.453
  • KRAS_SIGNALING_DN-0.363
  • IL6_JAK_STAT3_SIGNALING-0.362
  • MYOGENESIS-0.362
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.361
  • INFLAMMATORY_RESPONSE-0.359
  • ALLOGRAFT_REJECTION-0.356
  • COAGULATION-0.327
  • TNFA_SIGNALING_VIA_NFKB-0.314
  • COMPLEMENT-0.278

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_7G42J2SK
medullo-epn-umap@date-based
EPNSupratentorial EPN0.953
2BS_QXKRN6CR
medullo-epn-umap@date-based
EPNSupratentorial EPN0.944
3BS_QXKRN6CR
brain-umap@2
Supratentorial Ependymoma—0.935
4BS_G23JJAZY
brain-umap@2
Supratentorial Ependymoma—0.924
5BS_FTKPQ5FZ
brain-umap@2
Supratentorial Ependymoma—0.917
6BS_H4NXBD2D
brain-umap@2
Supratentorial Ependymoma—0.914
7BS_G23JJAZY
medullo-epn-umap@date-based
EPNSupratentorial EPN0.907
8BS_KSKZ9J7J
brain-umap@2
Embryonal tumors—0.898
9BS_052PZFMK
brain-umap@2
high-grade glioma—0.884
10SJEPD030854_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.882

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.468Inavolisib— uncovered
PROTEIN_SECRETION0.414Remibrutinib— uncovered
MYC_TARGETS_V10.413Inavolisib— uncovered
DNA_REPAIR0.374Idelalisib— uncovered
G2M_CHECKPOINT0.350Inavolisib— uncovered
MTORC1_SIGNALING0.339Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.338Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.274Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.268Remibrutinib— uncovered
MITOTIC_SPINDLE0.161Inavolisib— uncovered
NOTCH_SIGNALING0.138Inavolisib— uncovered
PEROXISOME0.118Idelalisib— uncovered
ANDROGEN_RESPONSE0.117Inavolisib— uncovered
GLYCOLYSIS0.106Inavolisib— uncovered
ADIPOGENESIS0.088Inavolisib— uncovered
BILE_ACID_METABOLISM0.067Inavolisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.059Inavolisib— uncovered
UV_RESPONSE_DN0.057Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.049Remibrutinib— uncovered
UV_RESPONSE_UP0.048Idelalisib— uncovered