Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-AN-A0XP-01A-11R-A109-07

· B

227814f7-590f-5783-89fa-831df5af4f1c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
0

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.730
  • PROTEIN_SECRETION+0.430
  • INTERFERON_GAMMA_RESPONSE+0.390
  • NOTCH_SIGNALING+0.380
  • ANGIOGENESIS+0.240
  • ESTROGEN_RESPONSE_EARLY+0.230
  • APOPTOSIS+0.180
  • HEME_METABOLISM+0.170
  • TGF_BETA_SIGNALING+0.170
  • CHOLESTEROL_HOMEOSTASIS+0.160

Top 10 suppressed

  • E2F_TARGETS-0.490
  • MYC_TARGETS_V2-0.400
  • ALLOGRAFT_REJECTION-0.390
  • G2M_CHECKPOINT-0.390
  • MYC_TARGETS_V1-0.390
  • MYOGENESIS-0.260
  • SPERMATOGENESIS-0.260
  • KRAS_SIGNALING_DN-0.240
  • APICAL_JUNCTION-0.210
  • IL6_JAK_STAT3_SIGNALING-0.180

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-D8-A1XY-01A-11R-A14M-07
breast-umap@18
A0.781
220030031.LumA
breast-umap@18
A0.761
3TCGA-86-8278-01A-11R-2287-07
lung-landscapes@6
cohortA10.697
4TCGA-A2-A0YC-01A-11R-A109-07
breast-umap@18
B0.690
5SRR25617898
breast-umap@18
A0.681
6TCGA-ZF-A9R3-01A-11R-A38B-07
bladder-landscape@3
0.678
7DRR168515
bladder-landscape@3
0.678
8TCGA-E9-A1RD-01A-11R-A157-07
breast-umap@18
B0.675
9TCGA-E2-A10E-01A-21R-A10J-07
breast-umap@18
B0.672
10TCGA-71-8520-01A-11R-2403-07
lung-landscapes@6
cohortA10.661

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.730Inavolisib— uncovered
PROTEIN_SECRETION0.430Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.390Idelalisib— uncovered
NOTCH_SIGNALING0.380Inavolisib— uncovered
ANGIOGENESIS0.240Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.230Inavolisib— uncovered
APOPTOSIS0.180Idelalisib— uncovered
HEME_METABOLISM0.170Temsirolimus— uncovered
TGF_BETA_SIGNALING0.170Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.160Remibrutinib— uncovered
APICAL_SURFACE0.150Temsirolimus— uncovered
ANDROGEN_RESPONSE0.140Inavolisib— uncovered
UV_RESPONSE_DN0.130Inavolisib— uncovered
P53_PATHWAY0.090Idelalisib— uncovered
HEDGEHOG_SIGNALING0.080Inavolisib— uncovered
ADIPOGENESIS0.060Inavolisib— uncovered
COMPLEMENT0.060Inavolisib— uncovered
COAGULATION0.050Binimetinib— uncovered
ESTROGEN_RESPONSE_LATE0.050Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.050Idelalisib— uncovered