SRR1340420
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V1+0.312
- OXIDATIVE_PHOSPHORYLATION+0.306
- DNA_REPAIR+0.302
- MYC_TARGETS_V2+0.166
- UNFOLDED_PROTEIN_RESPONSE+0.115
- KRAS_SIGNALING_DN+0.066
- PROTEIN_SECRETION+0.054
- PI3K_AKT_MTOR_SIGNALING+0.006
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.002
- SPERMATOGENESIS-0.004
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.586
- TNFA_SIGNALING_VIA_NFKB-0.527
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
- IL6_JAK_STAT3_SIGNALING-0.515
- INFLAMMATORY_RESPONSE-0.511
- INTERFERON_GAMMA_RESPONSE-0.508
- TGF_BETA_SIGNALING-0.491
- ANGIOGENESIS-0.487
- COAGULATION-0.446
- NOTCH_SIGNALING-0.442
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1499442 | GTEX | — | 0.988 |
| 2 | SRR1441141 | GTEX | — | 0.986 |
| 3 | SRR1316874 | GTEX | — | 0.985 |
| 4 | SRR604098 | GTEX | — | 0.983 |
| 5 | SRR1458422 | GTEX | — | 0.981 |
| 6 | SRR1429891 | GTEX | — | 0.980 |
| 7 | SRR1441118 | GTEX | — | 0.977 |
| 8 | SRR1393068 | GTEX | — | 0.975 |
| 9 | SRR1488751 | GTEX | — | 0.974 |
| 10 | SRR1407560 | GTEX | — | 0.973 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V1 | 0.312 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.306 | Remibrutinib | — uncovered |
| DNA_REPAIR | 0.302 | Idelalisib | — uncovered |
| MYC_TARGETS_V2 | 0.166 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.115 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.066 | Remibrutinib | — uncovered |
| PROTEIN_SECRETION | 0.054 | Remibrutinib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.006 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.002 | Inavolisib | — uncovered |