C3L-02968

— · cohortSQ2

24ecba93-a578-5ae3-9eda-72bebfff91ae

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortSQ2
subtype: cohortSQ2
age_years: 64.83778234

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

HTTPException: HTTP Error: Request returned HTTP 429 for HTTP HEAD to 'https://pub-e056b053afc04eec88337b62541f3025.r2.dev/oncoscape/lung-landscapes/6/gsva.parquet' LINE 1: SELECT pathway_library_id, pathway_name, gsva_score FROM read_parquet('https://pub-e056b053afc04eec88337b62541f3025... ^

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR33346959 bladder-landscape@3	—	—	0.741
2	8cb3ba59-cfa2-4529-87a4-80d3f7be1332 melanoma-umap@29	—	—	0.727
3	SRR8613767 breast-umap@18	—	E	0.711
4	MNG800 mng-umap@100	—	—	0.707
5	AUR-AFR5-TTP1-A-1-1-R-A743-41 breast-umap@18	—	D	0.666
6	TCGA-EW-A6SB-01A-12R-A32P-07 breast-umap@18	—	E	0.662
7	TCGA-E2-A1B6-01A-31R-A12P-07 breast-umap@18	—	D	0.654
8	TCGA-A2-A3Y0-01A-11R-A239-07 breast-umap@18	—	E	0.651
9	TCGA-OL-A5D7-01A-11R-A27Q-07 breast-umap@18	—	E	0.647
10	c4779698-5c81-4eed-80ac-80fdd47f658b colon-landscapes@1	—	—	0.646

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 21 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
MYC_TARGETS_V2	0.480	Idelalisib	— uncovered
ALLOGRAFT_REJECTION	0.340	Idelalisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.310	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.250	Remibrutinib	— uncovered
IL6_JAK_STAT3_SIGNALING	0.230	Inavolisib	— uncovered
INFLAMMATORY_RESPONSE	0.220	Idelalisib	— uncovered
SPERMATOGENESIS	0.140	Inavolisib	— uncovered
INTERFERON_GAMMA_RESPONSE	0.120	Idelalisib	— uncovered
P53_PATHWAY	0.120	Idelalisib	— uncovered
XENOBIOTIC_METABOLISM	0.120	Inavolisib	— uncovered
HEDGEHOG_SIGNALING	0.070	Inavolisib	— uncovered
IL2_STAT5_SIGNALING	0.070	Idelalisib	— uncovered
MYC_TARGETS_V1	0.070	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.060	Cobimetinib	— uncovered
E2F_TARGETS	0.050	Inavolisib	— uncovered
APICAL_SURFACE	0.040	Temsirolimus	— uncovered
ESTROGEN_RESPONSE_LATE	0.030	Idelalisib	— uncovered
KRAS_SIGNALING_UP	0.030	Inavolisib	— uncovered
PI3K_AKT_MTOR_SIGNALING	0.020	Inavolisib	— uncovered
TNFA_SIGNALING_VIA_NFKB	0.020	Inavolisib	— uncovered