MNG800
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
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GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1093 | — | — | 0.811 |
| 2 | SRR33346959 | — | — | 0.741 |
| 3 | TCGA-B6-A3ZX-01A-11R-A239-07 | — | D | 0.718 |
| 4 | MNG1078 | — | — | 0.713 |
| 5 | C3L-02968 | — | cohortSQ2 | 0.707 |
| 6 | MNG1183 | — | — | 0.704 |
| 7 | TCGA-A2-A3XS-01A-11R-A22U-07 | — | E | 0.702 |
| 8 | BS_XG0DBWVT | high-grade glioma | — | 0.685 |
| 9 | SRR934984 | — | — | 0.679 |
| 10 | SRR934978 | — | — | 0.679 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 15 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.423 | Idelalisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.254 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.244 | Remibrutinib | — uncovered |
| E2F_TARGETS | 0.223 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.191 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.186 | Remibrutinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.184 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.169 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.168 | Inavolisib | — uncovered |
| IL6_JAK_STAT3_SIGNALING | 0.157 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.148 | Cobimetinib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.091 | Inavolisib | — uncovered |
| COAGULATION | 0.063 | Binimetinib | — uncovered |
| KRAS_SIGNALING_UP | 0.048 | Inavolisib | — uncovered |
| COMPLEMENT | 0.047 | Inavolisib | — uncovered |