Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

D5191F3D-028E-401C-927E-483F6884BE39

25357440-f8b8-5730-adfc-efaba736f225

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
10.709592641261498
age_years
58
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C9EE359E-2F42-4D20-880D-FBF8B4953731
brain-umap@2
0.977
2SRR934965
brain-umap@2
0.973
3SRR934747
brain-umap@2
0.972
4AF0A7BAA-D031-4C9F-91B7-7034F2C49D72
brain-umap@2
0.970
5SRR934926
brain-umap@2
0.970
6113D7756-712E-4EB4-9993-BBAF3C41AFEF
brain-umap@2
0.970
7A678E1E5-E02D-49A1-BB2B-C91A60E6382E
brain-umap@2
0.970
8SRR934835
brain-umap@2
0.969
965F93AB7-AA99-49B5-8D59-7D0DE9CA9E34
brain-umap@2
0.965
10795FBB8C-0E74-477F-AA27-1CE97A4E90B9
brain-umap@2
0.965

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 42 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.570Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.549Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.532Inavolisib— uncovered
ANGIOGENESIS0.525Remibrutinib— uncovered
G2M_CHECKPOINT0.520Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.513Idelalisib— uncovered
MYC_TARGETS_V20.513Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.511Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.495Inavolisib— uncovered
TGF_BETA_SIGNALING0.489Inavolisib— uncovered
HYPOXIA0.478Idelalisib— uncovered
MYC_TARGETS_V10.471Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.471Idelalisib— uncovered
DNA_REPAIR0.435Idelalisib— uncovered
ALLOGRAFT_REJECTION0.424Idelalisib— uncovered
APOPTOSIS0.422Idelalisib— uncovered
MTORC1_SIGNALING0.415Inavolisib— uncovered
IL2_STAT5_SIGNALING0.395Idelalisib— uncovered
MITOTIC_SPINDLE0.380Inavolisib— uncovered
PROTEIN_SECRETION0.374Remibrutinib— uncovered