Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934835

2f8c1857-f67a-503b-a442-9f9d76887191

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
14.19185282522996
age_years
57
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • TNFA_SIGNALING_VIA_NFKB+0.584
  • UNFOLDED_PROTEIN_RESPONSE+0.581
  • G2M_CHECKPOINT+0.579
  • ANGIOGENESIS+0.574
  • MTORC1_SIGNALING+0.557
  • MYC_TARGETS_V1+0.547
  • HYPOXIA+0.535
  • E2F_TARGETS+0.533
  • IL6_JAK_STAT3_SIGNALING+0.528
  • MYC_TARGETS_V2+0.527

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.401
  • PANCREAS_BETA_CELLS-0.297
  • BILE_ACID_METABOLISM-0.274
  • MYOGENESIS-0.140
  • SPERMATOGENESIS-0.116
  • XENOBIOTIC_METABOLISM-0.085
  • FATTY_ACID_METABOLISM-0.023
  • PEROXISOME-0.006
  • ESTROGEN_RESPONSE_LATE+0.002
  • APICAL_SURFACE+0.035

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1C9EE359E-2F42-4D20-880D-FBF8B4953731
brain-umap@2
0.969
2D5191F3D-028E-401C-927E-483F6884BE39
brain-umap@2
0.969
3SRR934965
brain-umap@2
0.967
4SRR934837
brain-umap@2
0.962
51B940F72-3C90-43C4-9267-185F21D10AC9
brain-umap@2
0.961
62B311620-94F3-4B53-B66A-81AC0A32453B
brain-umap@2
0.956
7SRR934730
brain-umap@2
0.955
8SRR934926
brain-umap@2
0.954
965F93AB7-AA99-49B5-8D59-7D0DE9CA9E34
brain-umap@2
0.952
10SRR934958
brain-umap@2
0.951

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 42 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TNFA_SIGNALING_VIA_NFKB0.584Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.581Idelalisib— uncovered
G2M_CHECKPOINT0.579Inavolisib— uncovered
ANGIOGENESIS0.574Remibrutinib— uncovered
MTORC1_SIGNALING0.557Inavolisib— uncovered
MYC_TARGETS_V10.547Inavolisib— uncovered
HYPOXIA0.535Idelalisib— uncovered
E2F_TARGETS0.533Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.528Inavolisib— uncovered
MYC_TARGETS_V20.527Idelalisib— uncovered
INTERFERON_GAMMA_RESPONSE0.432Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.431Inavolisib— uncovered
GLYCOLYSIS0.424Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.420Inavolisib— uncovered
MITOTIC_SPINDLE0.389Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.386Idelalisib— uncovered
PROTEIN_SECRETION0.375Remibrutinib— uncovered
P53_PATHWAY0.367Idelalisib— uncovered
DNA_REPAIR0.358Idelalisib— uncovered
ANDROGEN_RESPONSE0.347Inavolisib— uncovered