s0122235
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- ESTROGEN_RESPONSE_EARLY+0.300
- WNT_BETA_CATENIN_SIGNALING+0.300
- APICAL_SURFACE+0.200
- BILE_ACID_METABOLISM+0.200
- HEME_METABOLISM+0.200
- P53_PATHWAY+0.200
- UV_RESPONSE_DN+0.200
- ESTROGEN_RESPONSE_LATE+0.100
- MITOTIC_SPINDLE+0.100
- MYOGENESIS+0.100
Top 10 suppressed
- MYC_TARGETS_V1-0.600
- E2F_TARGETS-0.500
- MYC_TARGETS_V2-0.500
- ALLOGRAFT_REJECTION-0.400
- G2M_CHECKPOINT-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- MTORC1_SIGNALING-0.400
- OXIDATIVE_PHOSPHORYLATION-0.400
- PANCREAS_BETA_CELLS-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | s0112264 | — | — | 0.903 |
| 2 | SRR1313116 | — | A | 0.899 |
| 3 | ERR2208935 | — | — | 0.891 |
| 4 | SRR8613714 | — | A | 0.888 |
| 5 | TCGA-BH-A0E9-01B-11R-A115-07 | — | A | 0.872 |
| 6 | TCGA-OL-A5RV-01A-12R-A28M-07 | — | A | 0.846 |
| 7 | TCGA-55-8097-01A-11R-2241-07 | — | cohortA1 | 0.844 |
| 8 | SRR8613701 | — | A | 0.843 |
| 9 | SRR6013544 | — | cohortA1 | 0.836 |
| 10 | TCGA-D8-A4Z1-01A-21R-A266-07 | — | A | 0.836 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| ESTROGEN_RESPONSE_EARLY | 0.300 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.300 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.200 | Temsirolimus | — uncovered |
| BILE_ACID_METABOLISM | 0.200 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.200 | Temsirolimus | — uncovered |
| P53_PATHWAY | 0.200 | Idelalisib | — uncovered |
| UV_RESPONSE_DN | 0.200 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.100 | Inavolisib | — uncovered |
| MYOGENESIS | 0.100 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.100 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.100 | Inavolisib | — uncovered |