Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-BH-A0EB-01A-11R-A034-07

· B

270b1b78-8cb8-595b-a8fd-1d53c76d054d

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
B
subtype
B
overall_survival_months
25
os_event
false

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ALLOGRAFT_REJECTION+0.470
  • INTERFERON_ALPHA_RESPONSE+0.460
  • PROTEIN_SECRETION+0.430
  • EPITHELIAL_MESENCHYMAL_TRANSITION+0.410
  • INTERFERON_GAMMA_RESPONSE+0.400
  • ANGIOGENESIS+0.360
  • COMPLEMENT+0.350
  • IL6_JAK_STAT3_SIGNALING+0.340
  • COAGULATION+0.320
  • INFLAMMATORY_RESPONSE+0.320

Top 10 suppressed

  • E2F_TARGETS-0.540
  • G2M_CHECKPOINT-0.480
  • MYC_TARGETS_V2-0.390
  • MITOTIC_SPINDLE-0.240
  • SPERMATOGENESIS-0.220
  • MYC_TARGETS_V1-0.210
  • GLYCOLYSIS-0.140
  • CHOLESTEROL_HOMEOSTASIS-0.130
  • WNT_BETA_CATENIN_SIGNALING-0.130
  • DNA_REPAIR-0.110

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-46-3766-01A-01R-0980-07
lung-landscapes@6
cohortSQ10.864
2TCGA-50-5049-01A-01R-1628-07
lung-landscapes@6
cohortA10.858
3TCGA-BT-A20Q-01A-11R-A14Y-07
bladder-landscape@3
0.858
4TCGA-05-4417-01A-22R-1858-07
lung-landscapes@6
cohortA30.849
5BS_53CTGDQG
brain-umap@2
Meningioma0.843
6SRR8518419
breast-umap@18
A0.832
7C3N-02090
lung-landscapes@6
cohortSQ10.832
852bfcfee-5de0-4e8f-9f11-7a643858bcb0
colon-landscapes@1
0.829
9BS_Z0AVVB1V
brain-umap@2
pilocytic astrocytoma0.827
10MDT-AP-2181
medullo-epn-umap@date-based
MedMedulloblastoma0.825

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 31 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ALLOGRAFT_REJECTION0.470Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.460Inavolisib— uncovered
PROTEIN_SECRETION0.430Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.410Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.400Idelalisib— uncovered
ANGIOGENESIS0.360Remibrutinib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.340Inavolisib— uncovered
COAGULATION0.320Binimetinib— uncovered
INFLAMMATORY_RESPONSE0.320Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.300Inavolisib— uncovered
ANDROGEN_RESPONSE0.270Inavolisib— uncovered
KRAS_SIGNALING_UP0.270Inavolisib— uncovered
IL2_STAT5_SIGNALING0.230Idelalisib— uncovered
UV_RESPONSE_DN0.220Inavolisib— uncovered
PANCREAS_BETA_CELLS0.210Cobimetinib— uncovered
APOPTOSIS0.180Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.170Remibrutinib— uncovered
TGF_BETA_SIGNALING0.170Inavolisib— uncovered
PEROXISOME0.160Idelalisib— uncovered