MNG760

—

273f8380-522e-55dd-9d4c-f6193a243308

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

OXIDATIVE_PHOSPHORYLATION+0.297
PANCREAS_BETA_CELLS+0.186
NOTCH_SIGNALING+0.057
KRAS_SIGNALING_DN+0.036
MYC_TARGETS_V1+0.028
UV_RESPONSE_UP-0.011
APICAL_JUNCTION-0.020
ADIPOGENESIS-0.021
SPERMATOGENESIS-0.025
CHOLESTEROL_HOMEOSTASIS-0.030

Top 10 suppressed

INTERFERON_ALPHA_RESPONSE-0.565
TNFA_SIGNALING_VIA_NFKB-0.519
INTERFERON_GAMMA_RESPONSE-0.507
IL6_JAK_STAT3_SIGNALING-0.457
HYPOXIA-0.382
ALLOGRAFT_REJECTION-0.381
APOPTOSIS-0.372
MITOTIC_SPINDLE-0.367
INFLAMMATORY_RESPONSE-0.346
REACTIVE_OXYGEN_SPECIES_PATHWAY-0.334

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR10899984 melanoma-umap@29	—	—	0.886
2	MNG199 mng-umap@100	—	—	0.883
3	SRR4296068 lung-landscapes@6	—	cohortA1	0.879
4	TCGA-37-4129-01A-01R-1100-07 lung-landscapes@6	—	cohortSC	0.875
5	TCGA-E9-A245-01A-22R-A16F-07 breast-umap@18	—	B	0.862
6	MNG341 mng-umap@100	—	—	0.857
7	SRR1516072 bladder-landscape@3	—	—	0.856
8	TCGA-E5-A4U1-01A-11R-A31N-07 bladder-landscape@3	—	—	0.856
9	c8b9a438-4194-4243-a738-4e0bd4184f19 melanoma-umap@29	—	—	0.856
10	MNG604 mng-umap@100	—	—	0.855

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
OXIDATIVE_PHOSPHORYLATION	0.297	Remibrutinib	— uncovered
PANCREAS_BETA_CELLS	0.186	Cobimetinib	— uncovered
NOTCH_SIGNALING	0.057	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.036	Remibrutinib	— uncovered
MYC_TARGETS_V1	0.028	Inavolisib	— uncovered