Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR6013603

· cohortA3

28709542-4970-5ada-8da0-219a6c94d671

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortA3
subtype
cohortA3

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR975592
colon-landscapes@1
0.831
2MDT-AP-0203
medullo-epn-umap@date-based
MedMedulloblastoma0.827
3SRR975564
colon-landscapes@1
0.825
4MNG732
mng-umap@100
0.794
5TCGA-PQ-A6FN-01A-11R-A31N-07
bladder-landscape@3
0.782
6A07BA2E1-CCA0-4231-A391-B13383A2BCB9
brain-umap@2
0.781
7BS_R439VVPK
medullo-epn-umap@date-based
MedMedulloblastoma0.780
8MNG1082
mng-umap@100
0.779
9TCGA-18-3411-01A-01R-0980-07
lung-landscapes@6
cohortSQ20.779
10BD887C3F-0002-4EC8-B845-9B38E78A3906
brain-umap@2
0.775

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.520Inavolisib— uncovered
G2M_CHECKPOINT0.440Inavolisib— uncovered
MTORC1_SIGNALING0.440Inavolisib— uncovered
MYC_TARGETS_V20.380Idelalisib— uncovered
MYC_TARGETS_V10.370Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.360Idelalisib— uncovered
DNA_REPAIR0.330Idelalisib— uncovered
ANGIOGENESIS0.290Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.290Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.270Remibrutinib— uncovered
HYPOXIA0.230Idelalisib— uncovered
UV_RESPONSE_UP0.220Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.210Inavolisib— uncovered
SPERMATOGENESIS0.210Inavolisib— uncovered
GLYCOLYSIS0.190Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.190Remibrutinib— uncovered
PEROXISOME0.180Idelalisib— uncovered
ALLOGRAFT_REJECTION0.130Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.130Idelalisib— uncovered
COMPLEMENT0.120Inavolisib— uncovered