Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

54B7F258-FE9A-4EFE-87FB-465D587B1170

297cd180-04f6-560b-ae44-c61d478ab91e

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
4.533508541392904
age_years
68
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1E97A62A3-E4D3-435C-9165-C0075358578E
brain-umap@2
0.950
2AB5294B5-4A59-493A-9016-C2778735745F
brain-umap@2
0.944
3812834CD-DA8F-4C0C-A49E-31D4A882D0E0
brain-umap@2
0.939
48730AABF-0720-4754-82B0-722150A485B8
brain-umap@2
0.939
5C5C8713B-05C1-4C5C-8685-2A546B99BA50
brain-umap@2
0.939
633800B09-6DCC-4BE8-891C-5F34ADAC65B3
brain-umap@2
0.938
7BB96C5BA-CA50-40B4-B22A-3FCFE46AB11C
brain-umap@2
0.937
894640BD8-E1D9-482D-A597-4790F6EEA6B7
brain-umap@2
0.935
9769432C5-4BFD-4689-8F43-467010292448
brain-umap@2
0.934
1052F6F0A9-8D2D-49BC-9B49-E20E5E53561C
brain-umap@2
0.933

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.561Inavolisib— uncovered
E2F_TARGETS0.550Inavolisib— uncovered
DNA_REPAIR0.491Idelalisib— uncovered
G2M_CHECKPOINT0.489Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.475Inavolisib— uncovered
MTORC1_SIGNALING0.463Inavolisib— uncovered
PROTEIN_SECRETION0.458Remibrutinib— uncovered
INTERFERON_GAMMA_RESPONSE0.440Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.396Remibrutinib— uncovered
NOTCH_SIGNALING0.370Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.349Inavolisib— uncovered
APOPTOSIS0.348Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.347Idelalisib— uncovered
ADIPOGENESIS0.344Inavolisib— uncovered
GLYCOLYSIS0.332Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.321Inavolisib— uncovered
PEROXISOME0.301Idelalisib— uncovered
ANGIOGENESIS0.299Remibrutinib— uncovered
IL6_JAK_STAT3_SIGNALING0.283Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.270Remibrutinib— uncovered