Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

E97A62A3-E4D3-435C-9165-C0075358578E

97d11cd7-d7b2-5161-bcab-157401af7615

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
4.566360052562418
age_years
63
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1812834CD-DA8F-4C0C-A49E-31D4A882D0E0
brain-umap@2
0.954
254B7F258-FE9A-4EFE-87FB-465D587B1170
brain-umap@2
0.950
36D1D9992-DA2B-419A-A80A-9EBCDA831754
brain-umap@2
0.947
46410821A-1C6A-4F64-939F-196313B8F1E5
brain-umap@2
0.943
5C14BEAAE-A766-4ADE-A9B4-674D8717591F
brain-umap@2
0.941
6BB96C5BA-CA50-40B4-B22A-3FCFE46AB11C
brain-umap@2
0.939
72E040577-EA0C-4876-9F43-A180DA38F733
brain-umap@2
0.933
8821FCEC2-41D4-48D9-8B75-D87405D075F7
brain-umap@2
0.929
9AB5294B5-4A59-493A-9016-C2778735745F
brain-umap@2
0.929
106B8CAF74-45C6-4C20-8126-A99F73346198
brain-umap@2
0.928

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 41 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
E2F_TARGETS0.596Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.580Inavolisib— uncovered
MYC_TARGETS_V10.548Inavolisib— uncovered
G2M_CHECKPOINT0.504Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.504Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.502Remibrutinib— uncovered
DNA_REPAIR0.488Idelalisib— uncovered
MTORC1_SIGNALING0.435Inavolisib— uncovered
MYC_TARGETS_V20.420Idelalisib— uncovered
ALLOGRAFT_REJECTION0.379Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.379Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.376Inavolisib— uncovered
ADIPOGENESIS0.371Inavolisib— uncovered
PROTEIN_SECRETION0.347Remibrutinib— uncovered
APOPTOSIS0.342Idelalisib— uncovered
PEROXISOME0.342Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.334Inavolisib— uncovered
FATTY_ACID_METABOLISM0.324Inavolisib— uncovered
BILE_ACID_METABOLISM0.321Inavolisib— uncovered
P53_PATHWAY0.299Idelalisib— uncovered