Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

R236

29d7efdc-bf39-5697-80e2-86830e048c5a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
81
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1AUR-AER7-TTM4-A-1-1-R-A742-41
breast-umap@18
E0.921
2SRR9879289
lung-landscapes@6
cohortSQ10.884
3MNG1237
mng-umap@100
0.882
4TCGA-GM-A3XN-01A-12R-A22U-07
breast-umap@18
A0.875
5R37
bladder-landscape@3
0.871
669d9a82b-5c37-45bd-a1cf-ffe1392e84fc
melanoma-umap@29
0.867
7SRR493947
lung-landscapes@6
cohortA10.864
8R24
bladder-landscape@3
0.863
9MNG110
mng-umap@100
0.862
10R89
bladder-landscape@3
0.862

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 24 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.400Remibrutinib— uncovered
P53_PATHWAY0.350Idelalisib— uncovered
KRAS_SIGNALING_DN0.330Remibrutinib— uncovered
TNFA_SIGNALING_VIA_NFKB0.320Inavolisib— uncovered
MYOGENESIS0.300Inavolisib— uncovered
HEDGEHOG_SIGNALING0.280Inavolisib— uncovered
COAGULATION0.260Binimetinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.260Inavolisib— uncovered
HYPOXIA0.260Idelalisib— uncovered
KRAS_SIGNALING_UP0.240Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.210Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.190Inavolisib— uncovered
NOTCH_SIGNALING0.170Inavolisib— uncovered
APICAL_JUNCTION0.160Inavolisib— uncovered
APICAL_SURFACE0.160Temsirolimus— uncovered
APOPTOSIS0.150Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.120Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.100Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.100Inavolisib— uncovered
ALLOGRAFT_REJECTION0.080Idelalisib— uncovered