MNG499
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.226
- ALLOGRAFT_REJECTION+0.150
- INTERFERON_ALPHA_RESPONSE+0.103
- INTERFERON_GAMMA_RESPONSE+0.095
- SPERMATOGENESIS+0.077
- COAGULATION+0.012
- APICAL_SURFACE+0.008
- PEROXISOME-0.008
- MYOGENESIS-0.024
- INFLAMMATORY_RESPONSE-0.040
Top 10 suppressed
- MTORC1_SIGNALING-0.435
- TGF_BETA_SIGNALING-0.417
- MYC_TARGETS_V2-0.399
- UNFOLDED_PROTEIN_RESPONSE-0.379
- E2F_TARGETS-0.376
- ANDROGEN_RESPONSE-0.369
- G2M_CHECKPOINT-0.368
- APOPTOSIS-0.363
- MYC_TARGETS_V1-0.332
- HYPOXIA-0.321
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-1327 | Med | Medulloblastoma | 0.910 |
| 2 | SRR8392892 | — | cohortA1 | 0.887 |
| 3 | TCGA-49-AAR2-01A-11R-A39D-07 | — | cohortA3 | 0.879 |
| 4 | SRR8942981 | — | — | 0.877 |
| 5 | TCGA-MP-A4T6-01A-32R-A262-07 | — | cohortA1 | 0.876 |
| 6 | aad89bba-d9dc-4a93-8e77-26f2c1ba1c3f | — | — | 0.875 |
| 7 | SRR11296732 | — | — | 0.869 |
| 8 | TCGA-92-8065-01A-11R-2247-07 | — | cohortSQ1 | 0.868 |
| 9 | MNG882 | — | — | 0.865 |
| 10 | MNG1246 | — | — | 0.865 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 7 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.226 | Remibrutinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.150 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.103 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.095 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.077 | Inavolisib | — uncovered |
| COAGULATION | 0.012 | Binimetinib | — uncovered |
| APICAL_SURFACE | 0.008 | Temsirolimus | — uncovered |